{"created":"2023-06-19T11:24:54.544698+00:00","id":5698,"links":{},"metadata":{"_buckets":{"deposit":"abf90c35-ffdb-4073-ba66-bc8dccaaa752"},"_deposit":{"created_by":1,"id":"5698","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5698"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005698","sets":["7","7:24"]},"author_link":["17785","17786","17781","17780","17779","17787","17782","17784","17783"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageEnd":"4798","bibliographicPageStart":"4791","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"Investigative ophthalmology and visual science"}]}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID:27618417","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PURPOSE:\n\\nAlthough endothelium-dependent nitric oxide (NO)-mediated dilation of retinal arterioles has been well described, the role of endothelium-derived hyperpolarizing factor (EDHF) in the retinal arteriolar response remains unclear. In the current study, we examined the contribution of EDHF to the retinal arteriolar dilation to the inflammatory agent histamine and investigated the signaling mechanisms underlying this vasomotor activity.\nMETHODS:\n\\nPorcine retinal arterioles were isolated, cannulated, and pressurized without flow for functional study by using video microscopic techniques. The immunohistochemical staining was performed to determine histamine receptor subtypes.\nRESULTS:\n\\nHistamine (0.1-30 μM) produced concentration-dependent dilation of retinal arterioles in a manner sensitive to H1- and H2-receptor antagonists chlorpheniramine and famotidine, respectively. Histamine-induced vasodilation was almost abolished after endothelial removal. In the intact vessels, vasodilation to histamine was partially inhibited by the inhibitors of cyclooxygenase (indomethacin), NO synthase (NG-nitro-L-arginine methyl ester, L-NAME), or Ca2+ -activated K+ (KCa) channels (apamin plus charybdotoxin). Combination of the above inhibitors abolished histamine-induced vasodilation. Residual vasodilation in the presence of indomethacin and L-NAME was further reduced by the cytochrome P450 enzyme inhibitor sulfaphenazole but not by the gap junction inhibitor carbenoxolone or the hydrogen peroxide scavenger catalase. Immunohistochemical signals for H1- and H2-receptor expression were found only in the endothelium.\nCONCLUSIONS:\n\\nThe endothelium plays an essential role in the dilation of porcine retinal arterioles to histamine via H1- and H2-receptor activation. The EDHF derived from cytochrome P450 contributed in part to this vasodilation via KCa channel activation, in addition to the endothelial release of NO and prostanoids.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1167/iovs.15-19038.","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0146-0404","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"27618417"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"598"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"496"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Otani, Shinichi"},{"subitem_text_value":"Nagaoka, Taiji"},{"subitem_text_value":"Omae, Tsuneaki"},{"subitem_text_value":"Tanano, Ichiro"},{"subitem_text_value":"Kamiya, Takayuki"},{"subitem_text_value":"Ono, Shinji"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"Yoshida, Akitoshi"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大谷, 真一"},{"creatorName":"オオタニ, シンイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17779","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長岡, 泰司"},{"creatorName":"ナガオカ, タイジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17780","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大前, 恒明"},{"creatorName":"オオマエ, ツネアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17781","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"棚野, 一郎"},{"creatorName":"タナノ, イチロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17782","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"神谷, 隆行"},{"creatorName":"カミヤ, タカユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17783","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大野, 晋治"},{"creatorName":"オオノ, シンジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17784","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Travis, W  Hein"}],"nameIdentifiers":[{"nameIdentifier":"17785","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lih, Kuo"}],"nameIdentifiers":[{"nameIdentifier":"17786","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 晃敏"},{"creatorName":"ヨシダ, アキトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17787","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"6757.pdf","filesize":[{"value":"6.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"6757.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/5698/files/6757.pdf"},"version_id":"8a0858dc-06f6-408f-a418-dad7b8c7f26d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Histamine-Induced Dilation of Isolated Porcine Retinal Arterioles: Role of Endothelium-Derived Hyperpolarizing Factor.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Histamine-Induced Dilation of Isolated Porcine Retinal Arterioles: Role of Endothelium-Derived Hyperpolarizing Factor."}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-07-20"},"publish_date":"2017-07-20","publish_status":"0","recid":"5698","relation_version_is_last":true,"title":["Histamine-Induced Dilation of Isolated Porcine Retinal Arterioles: Role of Endothelium-Derived Hyperpolarizing Factor."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:14:59.952507+00:00"}