{"created":"2023-06-19T11:24:54.316113+00:00","id":5694,"links":{},"metadata":{"_buckets":{"deposit":"a6f7d048-c158-4b7a-940c-84ec5c36b8e0"},"_deposit":{"created_by":1,"id":"5694","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5694"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005694","sets":["7","7:24"]},"author_link":["17757","17758","17756","17760","17754","17751","17761","17753","17747","17750","17752","17749","17748","17759","17755"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"OncoImmunology"}]}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID：27471649","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Tumor immune escape has been a major problem for developing effective immunotherapy. The human leukocyte antigen G (HLA-G) is a non-classical MHC class I molecule whose primary function is to protect the fetus from the mother's immune system. While HLA-G is hardly found in normal adult tissues, various tumor cells are known to express it, aiding their escape from the immune system. Thus, HLA-G is an attractive immunotherapy target. CD4+ helper T lymphocytes (HTLs) play an important role in the immune reaction against tumors by assisting in the generation and persistence of CD8+ cytotoxic T lymphocytes (CTLs) or by displaying direct antitumor effects. We report here that HLA-G expression in breast cancer significantly correlates with a poor prognosis. Also, we describe that the MHC class II-binding peptide HLA-G26–40 was effective in eliciting tumor-reactive CD4+ T cell responses. Furthermore, treatment with the DNA methyltransferase inhibitor 5-aza-2′-deoxycytidine increased HLA-G expression in tumors and subsequently enhanced recognition by HLA-G26–40-specific HTLs. These findings predict that a combination immunotherapy targeting HLA-G together with a DNA methyltransferase inhibitor could be useful against some cancers.","subitem_description_type":"Abstract"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1080/2162402X.2016.1169356","subitem_relation_type_select":"DOI"}}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"27471649"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"574"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"378"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Ishibashi,Kei"},{"subitem_text_value":"Kumai, Takumi"},{"subitem_text_value":"Ohkuri, Takayuki"},{"subitem_text_value":"Kosaka, Akemi"},{"subitem_text_value":"Nagato, Toshihiro"},{"subitem_text_value":"Hirata, Yui"},{"subitem_text_value":"Ohara, Kenzo"},{"subitem_text_value":"Oikawa, Kensuke"},{"subitem_text_value":"Aoki, Naoko"},{"subitem_text_value":"Akiyama, Naoko"},{"subitem_text_value":"Sado, Masatoshi"},{"subitem_text_value":"Kitada, Masahiro"},{"subitem_text_value":"Harabuchi, Yasuaki"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"Kobayashi, Hiroya"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石橋, 佳"},{"creatorName":"イシバシ, ケイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17747","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊井, 琢美"},{"creatorName":"クマイ, タクミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17748","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大栗, 敬幸"},{"creatorName":"オオクリ, タカユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17749","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小坂, 朱"},{"creatorName":"コサカ, アケミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17750","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長門, 利純"},{"creatorName":"ナガト, トシヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17751","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平田, 結"},{"creatorName":"ヒラタ, ユイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17752","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大原, 賢三"},{"creatorName":"オオハラ, ケンゾウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17753","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"及川, 賢輔"},{"creatorName":"オイカワ, ケンスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17754","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木, 直子"},{"creatorName":"アオキ, ナオコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17755","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"秋山, 直子"},{"creatorName":"アキヤマ, ナオコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17756","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐渡, 正敏"},{"creatorName":"サド, マサトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17757","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北田, 正博"},{"creatorName":"キタダ, マサヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17758","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原渕, 保明"},{"creatorName":"ハラブチ, ヤスアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17759","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Esteban, Celis"}],"nameIdentifiers":[{"nameIdentifier":"17760","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林, 博也"},{"creatorName":"コバヤシ, ヒロヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17761","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"6511.pdf","filesize":[{"value":"13.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"6511.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/5694/files/6511.pdf"},"version_id":"c309cc6a-ffc1-4e4b-9298-b8a2b3ab0501"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Human leukocyte antigen G","subitem_subject_scheme":"Other"},{"subitem_subject":"immune escape","subitem_subject_scheme":"Other"},{"subitem_subject":"immunotherapy","subitem_subject_scheme":"Other"},{"subitem_subject":"peptide vaccine","subitem_subject_scheme":"Other"},{"subitem_subject":"5-aza-2′-deoxycytidine","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Epigenetic modification augments the immunogenicity of human leukocyte antigen G serving as a tumor antigen for T cell-based immunotherapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Epigenetic modification augments the immunogenicity of human leukocyte antigen G serving as a tumor antigen for T cell-based immunotherapy"}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-07-15"},"publish_date":"2016-07-15","publish_status":"0","recid":"5694","relation_version_is_last":true,"title":["Epigenetic modification augments the immunogenicity of human leukocyte antigen G serving as a tumor antigen for T cell-based immunotherapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:15:07.671535+00:00"}