{"created":"2023-06-19T11:24:53.007263+00:00","id":5669,"links":{},"metadata":{"_buckets":{"deposit":"0570c3e6-7250-4ec2-8339-e54442752f1d"},"_deposit":{"created_by":1,"id":"5669","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5669"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005669","sets":["7","7:24"]},"author_link":["17694","17698","17697","17701","17702","17696","17699","17703","17695","17700"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-08-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"12","bibliographicPageStart":"1","bibliographicVolumeNumber":"7","bibliographic_titles":[{"bibliographic_title":"Nature communications"}]}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID：27507542","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Previous reports have suggested that some probiotics inhibit tumorigenesis and cancer progression. However, the molecules involved have not yet been identified. Here, we show that the culture supernatant of Lactobacillus casei ATCC334 has a strong tumour-suppressive effect on colon cancer cells. Using mass spectrometry, we identify ferrichrome as a tumour-suppressive molecule produced by L. casei ATCC334. The tumour-suppressive effect of ferrichrome is greater than that of cisplatin and 5-fluorouracil, and ferrichrome has less of an effect on non-cancerous intestinal cells than either of those agents. A transcriptome analysis reveals that ferrichrome treatment induces apoptosis, which is mediated by the activation of c-jun N-terminal kinase (JNK). Western blotting indicates that the induction of apoptosis by ferrichrome is reduced by the inhibition of the JNK signalling pathway. This we demonstrate that probiotic-derived ferrichrome exerts a tumour-suppressive effect via the JNK signalling pathway.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This work is licensed under a Creative Commons Attribution 4.0 International License.","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/ncomms12365.","subitem_relation_type_select":"DOI"}}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"27507542"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"572"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"983"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Konishi, Hiroaki"},{"subitem_text_value":"Fujiya, Mikihiro"},{"subitem_text_value":"Tanaka, Hiroki"},{"subitem_text_value":"Ueno, Nobuhiro"},{"subitem_text_value":"Moriichi, Kentaro"},{"subitem_text_value":"Sasajima, Junpei"},{"subitem_text_value":"Ikuta, Katsuya"},{"subitem_text_value":"Akutsu, Hiroaki"},{"subitem_text_value":"Tanabe, Hiroki"},{"subitem_text_value":"Kohgo, Yutaka"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小西, 弘晃"},{"creatorName":"コニシ, ヒロアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17694","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤谷, 幹浩"},{"creatorName":"フジヤ, ミキヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17695","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中, 宏樹"},{"creatorName":"タナカ, ヒロキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17696","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上野, 伸展"},{"creatorName":"ウエノ, ノブヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17697","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"盛一, 健太郎"},{"creatorName":"モリイチ, ケンタロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17698","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"笹嶋, 順平"},{"creatorName":"ササジマ, ジュンペイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17699","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"生田, 克哉"},{"creatorName":"イクタ, カツヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17700","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"阿久津, 弘明"},{"creatorName":"アクツ, ヒロアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17701","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田邊, 裕貴"},{"creatorName":"タナベ, ヒロキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17702","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高後, 裕"},{"creatorName":"コウゴ, ユタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17703","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"6727.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"6727.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/5669/files/6727.pdf"},"version_id":"98e3cd7d-3654-4fa1-91a3-8694072ca75b"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis"}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-06-12"},"publish_date":"2017-06-12","publish_status":"0","recid":"5669","relation_version_is_last":true,"title":["Probiotic-derived ferrichrome inhibits colon cancer progression via JNK-mediated apoptosis"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:15:47.125952+00:00"}