| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-08-24 |
| タイトル |
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タイトル |
Fibrates suppress chenodeoxycholic acid-induced RANTES expression through inhibition of NF-κ B activation |
|
言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
平野, 史倫
Hirano, Y
Fujii, H
Makino, I
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| 著者 ローマ字 |
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Hirano, Fuminori |
| 書誌情報 |
EUROPEAN JOURNAL OF PHARMACOLOGY
巻 448,
号 1,
p. 19-26,
発行日 2002-01-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0014-2999 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/S0014-2999(02)01902-7 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.sciencedirect.com/science/journal/00142999 | http://www.sciencedirect.com/science/journal/00142999 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Fibrates, hypolipidemic agents, are reported to be effective in treatment of primary biliary cirrhosis. However, the mechanism involved in therapeutic benefits of fibrates in primary biliary cirrhosis remains unknown. In contrast, hepatic regulated upon activation, normal T-cell expressed and secreted (RANTES) is increased in patients with primary biliary cirrhosis and bile acids up-regulate RANTES expression in hepatocytes. The role of fibrates in bile acid-induced RANTES expression was investigated in human hepatoma cells; 100 μM of bezafibrate and fenofibrate decreased expression of chenodeoxycholic acid-induced RANTES mRNA and protein. In addition, luciferase enzyme assay using RANTES promoter-luciferase reporter plasmid revealed that 100 μM of bezafibrate and fenofibrate transcriptionally reduced chenodeoxycholic acid-induced RANTES gene expression. Moreover, bezafibrate clearly repressed DNA-binding activity of nuclear factor-κB (NF-κB) induced by chenodeoxycholic acid. Therefore, fibrates might be inhibitory agents of inflammatory cell migration by RANTES to the liver in patients with primary biliary cirrhosis, possibly indicating that fibrates are therapeutic agents in primary biliary cirrhosis. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
Elsevier , Hirano, Y; Hirano, F; Fujii, H; Makino, I, EUROPEAN JOURNAL OF PHARMACOLOGY, 448(1), 2002, 19-26.
\nauthor |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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12126966 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1134 |
703.pdf (1.5 MB)
