{"created":"2023-06-19T11:20:30.927943+00:00","id":557,"links":{},"metadata":{"_buckets":{"deposit":"6be8d0e4-aa75-492d-b889-f12471e5e06e"},"_deposit":{"created_by":3,"id":"557","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"557"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00000557","sets":["7","7:23"]},"author_link":["1019","1020","1021","1022","1023","1024","1025","1026","1027"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"52","bibliographicPageStart":"51","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"肝臓"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"非アルコール性脂肪性肝炎(NASH)患者8例に,アンギオテンシンIIの1型受容体(AT1R)の選択的拮抗薬であるロサルタン(50mg/day)を24週間連続投与し,投与前後の血中の肝線維化マーカー,TGF-β1,肝脾CT値比を測定した.全例に副作用は認めなかった.投与前と比べ投与後では収縮期および拡張期血圧,血中トランスアミナーゼ値は有意に低下した.血中肝線維化マーカーのヒアルロン酸,IV型コラーゲン7S,III型プロコラーゲンN末端ペプチドおよび血中TGF-β1値は,投与前に比較して投与12及び24週目で有意に低下した.また投与前後の肝脾CT値比,血中脂質マーカーに有意な変化は認めなかった.AT1R拮抗薬は,その抗線維化作用を介してNASHに対する治療薬として有用であることが示唆された","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"著者最終原稿版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0451-4203","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2004182560"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1923"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"841"}]},"item_5_text_7":{"attribute_name":"著者 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