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Alloreactivity and immunosuppressive properties of articular chondrocytes from osteoarthritic cartilage.
https://asahikawa-med.repo.nii.ac.jp/records/5527
https://asahikawa-med.repo.nii.ac.jp/records/552738a18356-1a37-4d7b-993e-86c30fec6468
名前 / ファイル | ライセンス | アクション |
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Item type | 学位論文 / Thesis or Dissertation_02(1) | |||||
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公開日 | 2016-07-13 | |||||
タイトル | ||||||
タイトル | Alloreactivity and immunosuppressive properties of articular chondrocytes from osteoarthritic cartilage. | |||||
言語 | en | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | chondrocytes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | immune system | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | osteoarthritis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
阿部, 里見
× 阿部, 里見 |
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著者 ローマ字 | ||||||
値 | Abe, Satomi | |||||
書誌情報 |
Journal of orthopaedic surgery (Hong Kong) 巻 24, 号 2, p. 232-239, 発行日 2016-08-01 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1022-5536 | |||||
識別番号 その他 | ||||||
内容記述タイプ | Other | |||||
内容記述 | PMID:27574269 | |||||
学位授与番号 | ||||||
学位授与番号 | 乙463 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2016-06-30 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 10107 | |||||
学位授与機関名 | 旭川医科大学 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | PURPOSE: \nTo determine whether articular chondrocytes derived from osteoarthritic knee joints could evoke alloreactive proliferation of peripheral blood mononuclear cells (PBMC) and inhibit mitogenic activity of polyclonally activated CD4+ major histocompatibility complex (MHC) class II- restricted T cells in vitro. METHODS: \nOsteoarthritic cartilages of 17 patients aged 61 to 85 years were harvested during total knee arthroplasty. Chondrocytes were cultured for experiments. PBMCs, CD4+ T cells, CD8+ T cells, and CD14+ monocytes from healthy subjects were also used. To investigate the allogeneic response and immunosuppressive properties of chondrocytes, assays for one-way mixed lymphocyte reaction (MLR), apoptosis, activated CD4+ T-cell proliferation, and cytotoxic CD8+ T-cells were performed. Chondrocyte cell-surface antigens were examined using flow cytometry. RESULTS: \nChondrocytes failed to trigger an allogeneic PBMC reaction and did not induce apoptosis of allogeneic PBMCs in the MLR assay. Chondrocytes inhibited the proliferation of polyclonally activated CD4+ T cells via cell-cell contact and escaped the allogeneic cytotoxic reactivity of CD8+ T cells. Chondrocytes expressed MHC class I but not MHC class II molecules or B7-1/-2-positive co-stimulatory molecules. CONCLUSION: \nChondrocytes from osteoarthritic knees in older patients exhibited similar immunomodulatory properties in vitro to those in juveniles or adults. |
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資源タイプ | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
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出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf |