{"created":"2023-06-19T11:24:45.180035+00:00","id":5514,"links":{},"metadata":{"_buckets":{"deposit":"ecadf63a-cf9a-49f2-8731-2152e3b594ae"},"_deposit":{"created_by":1,"id":"5514","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5514"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005514","sets":["7","7:24"]},"author_link":["17244","17245","17240","17237","17238","17242","17243","17239","17246","17241"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1159","bibliographicPageStart":"1150","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Biochimica et Biophysica Acta (BBA) - General Subjects"}]}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID:.22001438","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND:\n\\nScavenger receptors are generally expressed in macrophages and vascular endothelial cells and some scavenger receptors are thought to contribute to the development of atherosclerosis.\nMETHODS:\n\\nWe cloned the cDNA of a zebrafish CL-P1 (collectin placenta 1) and performed a knockdown study using its antisense morpholino oligonucleotides (MO).\nRESULTS:\n\\nZebrafish CL-P1 (zCL-P1) is 51% identical to human CL-P1 in its amino acid sequence. Microbes and OxLDL bound to zCL-P1 cDNA transfected cells. zCL-P1 mRNA expression gradually increased after 6hours post-fertilization (hpf), reached its highest level at 24hpf, and then decreased, which is similar to the gene expression pattern of Tie-2. The knockdown of zCL-P1 led to an increase in the number of zebrafish embryos with severe morphological abnormalities such as short body lengths and defects in the dorsal aorta at 48hpf. Simultaneous injection of both MO and synthetic zCL-P1 or zVEGF mRNA rescued the abnormal phenotype.\nCONCLUSIONS:\n\\nIn vivo knockdown study shows that zCL-P1 is implicated in vasculogenesis and those of our in vitro study support its role as a scavenger receptor.\nGENERAL SIGNIFICANCE:\n\\nThese results suggest that zCL-P1 might be essential for vasculogenesis during the early embryonic phase in bone fish.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"CC-BY-NC-ND","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-3002","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"22001438"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"474"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"954"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Fukuda, Mitsuko"},{"subitem_text_value":"Ohtani, Katsuki"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"Yoshizaki, Takayuki"},{"subitem_text_value":"Mori, Ken-ichiro"},{"subitem_text_value":"Motomura, Wataru"},{"subitem_text_value":"Yoshida, Itsuro"},{"subitem_text_value":"Suzuki, Yasuhiko"},{"subitem_text_value":"Kohgo, Yutaka"},{"subitem_text_value":"Wakamiya, Nobutaka"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"福田, 光子"},{"creatorName":"フクダ, ミツコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17237","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大谷, 克城"},{"creatorName":"オオタニ, カツキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17238","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jang, Seong-Jae"}],"nameIdentifiers":[{"nameIdentifier":"17239","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉崎, 隆之"},{"creatorName":"ヨシザキ, タカユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17240","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"森, 健一郎"},{"creatorName":"モリ, ケンイチロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17241","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"本村, 亘"},{"creatorName":"モトムラ, ワタル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17242","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田, 逸朗"},{"creatorName":"ヨシダ, イツロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17243","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 定彦"},{"creatorName":"スズキ, ヤスヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17244","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高後, 裕"},{"creatorName":"コウゴ, ユタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17245","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"若宮, 伸隆"},{"creatorName":"ワカミヤ, ノブタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17246","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"6525.pdf","filesize":[{"value":"868.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"6525.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/5514/files/6525.pdf"},"version_id":"758817b0-f726-4403-b453-a80c0f0327a7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Collectin","subitem_subject_scheme":"Other"},{"subitem_subject":"Scavenger receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"Innate immunity","subitem_subject_scheme":"Other"},{"subitem_subject":"Zebrafish","subitem_subject_scheme":"Other"},{"subitem_subject":"Embryogenesis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Molecular cloning and functional analysis of scavenger receptor zebrafish CL-P1","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Molecular cloning and functional analysis of scavenger receptor zebrafish CL-P1"}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-08-17"},"publish_date":"2016-08-17","publish_status":"0","recid":"5514","relation_version_is_last":true,"title":["Molecular cloning and functional analysis of scavenger receptor zebrafish CL-P1"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:19:30.577837+00:00"}