| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2016-07-15 |
| タイトル |
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タイトル |
Increased dosage of infliximab is a potential cause of Pneumocystis carinii pneumonia |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
岩間, 琢哉
坂谷, 慧
藤谷, 幹浩
田中, 一之
藤林, 周吾
野村, 好紀
上野, 伸展
嘉島, 伸
後藤, 拓磨
笹島, 順平
盛一, 健太郎
生田, 克哉
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| 著者 ローマ字 |
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Iwama, Takuya |
| 著者 ローマ字 |
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Sakatani, Aki |
| 著者 ローマ字 |
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Fujiya, Mikihiro |
| 著者 ローマ字 |
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Tanaka, Kazuyuki |
| 著者 ローマ字 |
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Fujibayashi, Shugo |
| 著者 ローマ字 |
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Nomura, Yoshiki |
| 著者 ローマ字 |
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Ueno, Nobuhiro |
| 著者 ローマ字 |
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Kashima, Shin |
| 著者 ローマ字 |
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Goto, Takuma |
| 著者 ローマ字 |
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Sasajima, Junpei |
| 著者 ローマ字 |
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Moriichi, Kentaro |
| 著者 ローマ字 |
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Ikuta, Katsuya |
| 書誌情報 |
Gut Pathogens
巻 8,
号 2,
p. 1-3,
発行日 2016-02-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1757-4749 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1186/s13099-016-0086-4 |
| 識別番号 その他 |
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内容記述タイプ |
Other |
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内容記述 |
PMID:26839596 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
METHODS:
\nPneumocystis carinii pneumonia occasionally appears in immunodeficient patients. While several reports have shown that Pneumocystis carinii pneumonia occurred in the early phase of starting infliximab treatment in patients with Crohn's disease (CD), the present case suggests for the first time that an increased dosage of infliximab may also lead to pneumonia.
RESULTS:
\nA 51-year-old male had been taking 5 mg of infliximab for the treatment of CD for 10 years with no adverse events. Beginning in September 2013, the dose of infliximab had to be increased to 10 mg/kg because his status worsened. Thereafter, he complained of a fever and cough, and a CT scan revealed ground-glass opacities in the lower lobes of the bilateral lung with a crazy-paving pattern. Bronchoscopy detected swelling of the tracheal mucosa with obvious dilations of the vessels. A polymerase chain reaction using a bronchoalveolar lavage fluid sample detected specific sequences for Pneumocystis jirovecii; thus he was diagnosed with Pneumocystis carinii (jirovecii) pneumonia. After discontinuing infliximab and starting antibiotic treatment, his symptoms and CT findings were dramatically improved.
CONCLUSIONS:
\nThe administration of an increased dosage of infliximab can cause Pneumocystis carinii pneumonia in CD patients |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
http://creativecommons.org/licenses/by/4.0/ |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
VoR |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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26839596 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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802 |
6512.pdf (1.1 MB)
