{"created":"2023-06-19T11:24:43.389967+00:00","id":5481,"links":{},"metadata":{"_buckets":{"deposit":"8abe22b2-319b-419f-8c81-b3314a86dbab"},"_deposit":{"created_by":1,"id":"5481","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5481"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005481","sets":["7","7:24"]},"author_link":["17116","17122","17123","17117","17121","17124","17119","17118","17120"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"205","bibliographicPageStart":"198","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"Journal of Anesthesia"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://link.springer.com/article/10.1007%2Fs00540-014-1908-5 | http://link.springer.com/article/10.1007%2Fs00540-014-1908-5","subitem_description_type":"Other"}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID:25186494","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PURPOSE:\n\\nWe previously determined the pharmacokinetic (PK) parameters of landiolol in healthy male volunteers. In this study, we evaluated the usefulness of target-controlled infusion (TCI) of landiolol hydrochloride and determined PK parameters of landiolol in gynecologic patients.\nMETHODS:\n\\nNine patients who were scheduled to undergo gynecologic surgery were enrolled. After inducing anesthesia, landiolol hydrochloride was administered at the target plasma concentrations of 500 and 1,000 ng/mL for each 30 min. A total of 126 data points of plasma concentration were collected from the patients and used for the population PK analysis. Furthermore, a population PK model was developed using the nonlinear mixed-effect modeling software.\nRESULTS:\n\\nThe patients had markedly decreased heart rates (HRs) at 2 min after the initiation of landiolol hydrochloride administration; however, their blood pressures did not markedly change from the baseline value. The concentration time course of landiolol was best described by a 2-compartment model with lag time. The estimate of PK parameters were total body clearance (CL) 34.0 mL/min/kg, distribution volume of the central compartment (V 1) 74.9 mL/kg, inter-compartmental clearance (Q) 70.9 mL/min/kg, distribution volume of the peripheral compartment (V 2) 38.9 mL/kg, and lag time (ALAG) 0.634 min. The predictive performance of this model was better than that of the previous model.\nCONCLUSION:\n\\nTCI of landiolol hydrochloride is useful for controlling HR, and the PK parameters of landiolol in gynecologic patients were similar to those in healthy male volunteers and best described by a 2-compartment model with lag time.","subitem_description_type":"Abstract"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00540-014-1908-5","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0913-8668","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"25186494"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"562"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"808"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Kunisawa, Takayuki"},{"subitem_text_value":"Yamagishi, Akio"},{"subitem_text_value":"Suno, Manabu"},{"subitem_text_value":"Nakade, Susumu"},{"subitem_text_value":"Higashi, Ryunosuke"},{"subitem_text_value":"Kurosawa, Atsushi"},{"subitem_text_value":"Sugawara, Ami"},{"subitem_text_value":"Matsubara, Kazuo"},{"subitem_text_value":"Iwasaki, Hiroshi"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"国沢, 卓之"},{"creatorName":"クニサワ, タカユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17116","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山岸, 昭夫"},{"creatorName":"ヤマギシ, アキオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17117","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"須野, 学"},{"creatorName":"スノ, マナブ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17118","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中出, 進"},{"creatorName":"ナカデ, ススム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17119","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東, 龍之介"},{"creatorName":"ヒガシ, リュウノスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17120","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"黒澤, 温"},{"creatorName":"クロサワ, アツシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17121","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"菅原, 亜美"},{"creatorName":"スガワラ, アミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17122","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松原, 和夫"},{"creatorName":"マツバラ, カズオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17123","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岩崎, 寛"},{"creatorName":"イワサキ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"17124","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"6181.pdf","filesize":[{"value":"5.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"6181.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/5481/files/6181.pdf"},"version_id":"779f7a17-2548-4b8d-a769-046cfe6f4834"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Landiolol hydrochloride","subitem_subject_scheme":"Other"},{"subitem_subject":"Pharmacokinetics","subitem_subject_scheme":"Other"},{"subitem_subject":"Target-controlled infusion","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Target-controlled infusion and population pharmacokinetics of landiolol hydrochloride in gynecologic patients.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Target-controlled infusion and population pharmacokinetics of landiolol hydrochloride in gynecologic patients."}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-08-20"},"publish_date":"2015-08-20","publish_status":"0","recid":"5481","relation_version_is_last":true,"title":["Target-controlled infusion and population pharmacokinetics of landiolol hydrochloride in gynecologic patients."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:20:17.390862+00:00"}