{"created":"2023-06-19T11:24:38.962685+00:00","id":5399,"links":{},"metadata":{"_buckets":{"deposit":"47bcac41-3afb-4016-b40e-9dc95bc7ab62"},"_deposit":{"created_by":1,"id":"5399","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5399"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005399","sets":["7","7:27","7:27:41"]},"author_link":["16944"],"item_5_alternative_title_2":{"attribute_name":"タイトル ローマ字","attribute_value_mlt":[{"subitem_alternative_title":"Ubiquitin carboxy terminal hydrolase 1(UCH L1) interacts with Ubiquitin and upregulates free Ubiquitin level"}]},"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4-5","bibliographicPageEnd":"223","bibliographicPageStart":"219","bibliographicVolumeNumber":"86","bibliographic_titles":[{"bibliographic_title":"北海道医学雑誌"}]}]},"item_5_degree_grantor_32":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"旭川医科大学"}]}]},"item_5_degree_name_31":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年、ユビキチンC末端水解酵素1型(UCH L1)二量体がユビキチンリガーゼ活性を有すること、UCH L1がユビキチンと結合して神経系におけるユビキチンレベルの調整に重要な役割を果たしていることが明らかになった。UCH L1と結合し相互作用する蛋白質を明らかにするため、N末端6×ヒスチジンタグ付きUCH L1結合カラムを用いたアフィニティークロマトグラフィーの後、ペプチドマッピングを行った。その結果、UCH L1と相互作用する蛋白質としてこれまで報告されているJAB1、p27kip1の他に、ミエリン塩基性蛋白質(MBP)、α1-チューブリン、グリセルアルデヒド-3-リン酸脱水素酵素(GAPDH)、2',3'-環状ヌクレオチド3'-ホスホジエステラーゼ(CNPase)が候補蛋白質として挙げられた。","subitem_description_type":"Abstract"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_dissertation_number_29":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"10107A284"}]},"item_5_relation_27":{"attribute_name":"医中誌ID","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"2012103660","subitem_relation_type_select":"ICHUSHI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0367-6102","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2012103660"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"583"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1237"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Takizawa, Shuichi"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"滝沢, 修一"},{"creatorName":"タキザワ, シュウイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16944","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"6392.pdf","filesize":[{"value":"466.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"6392.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/5399/files/6392.pdf"},"version_id":"c8b285c7-cfac-4844-8c25-81d87f1bdbfd"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ユビキチンC末端水解酵素1型(UCH L1)に相互作用するタンパク質の検索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ユビキチンC末端水解酵素1型(UCH L1)に相互作用するタンパク質の検索"}]},"item_type_id":"5","owner":"1","path":["6","7","27","41"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-04-19"},"publish_date":"2016-04-19","publish_status":"0","recid":"5399","relation_version_is_last":true,"title":["ユビキチンC末端水解酵素1型(UCH L1)に相互作用するタンパク質の検索"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:22:13.018453+00:00"}