{"created":"2023-06-19T11:24:36.974533+00:00","id":5357,"links":{},"metadata":{"_buckets":{"deposit":"f9093ce3-92cf-4e5f-956a-67d40deecb1c"},"_deposit":{"created_by":1,"id":"5357","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5357"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005357","sets":["7","7:24"]},"author_link":["16798","16796","16795","16797","16800","16802","16803","16799","16801","16794"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-11-01","bibliographicIssueDateType":"Issued"},"bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://www.nature.com/articles/srep16280 | http://www.nature.com/articles/srep16280","subitem_description_type":"Other"}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID:26538233","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"HER-3 expression has been reported to act as an important oncoprotein in head and neck squamous cell carcinoma. This protein is known to control tumor proliferation and acquisition of resistance by tumor cells towards EGFR inhibitors, therefore, development of a HER-3-targeted therapy is desirable. In this study, we found that HER-3 expression on tumor cells was increased after EGFR inhibition. To establish a novel therapeutic approach for HER-3-positive head and neck carcinoma, we identified a HER-3 helper epitope that could elicit effective helper T cell responses to the naturally processed HER-3-derived epitope presented in a HER-3 expressing tumors. This epitope induced potent cytolytic activity of CD4 T cells against such tumor cells. Moreover, pan HER-family tyrosine kinase inhibitor augmented the responses of HER-3-reactive CD4 T cells via upregulation of HLA-DR protein on the surface of tumor cells. Our results supports the validity of CD4 T cell-dependent HER-3-targeted therapy combined with a broad inhibitor of HER-family.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"This work is licensed under a Creative Commons Attribution 4.0 International License.","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/srep16280.","subitem_relation_type_select":"DOI"}}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"26538233"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"643"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"921"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Kumai, Takumi"},{"subitem_text_value":"Ohkuri, Takayuki"},{"subitem_text_value":"Nagato, Toshihiro"},{"subitem_text_value":"Matsuda, Yoshinari"},{"subitem_text_value":"Oikawa, Kensuke"},{"subitem_text_value":"Aoki, Naoko"},{"subitem_text_value":"Kimura, Shoji"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"Harabuchi, Yasuaki"},{"subitem_text_value":"Kobayashi, Hiroya"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"熊井, 琢美"},{"creatorName":"クマイ, タクミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16794","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大栗, 敬幸"},{"creatorName":"オオクリ, タカユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16795","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長門, 利純"},{"creatorName":"ナガト, トシヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松田, 佳也"},{"creatorName":"マツダ, ヨシナリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"及川, 賢輔"},{"creatorName":"オイカワ, ケンスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16798","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木, 直子"},{"creatorName":"アオキ, ナオコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16799","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村, 昭冶"},{"creatorName":"キムラ, ショウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16800","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Esteban, Celis"}],"nameIdentifiers":[{"nameIdentifier":"16801","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原渕, 保明"},{"creatorName":"ハラブチ, ヤスアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16802","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小林, 博也"},{"creatorName":"コバヤシ, ヒロヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16803","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"6329.pdf","filesize":[{"value":"1.4 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carcinoma."}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-01-22"},"publish_date":"2016-01-22","publish_status":"0","recid":"5357","relation_version_is_last":true,"title":["Targeting HER-3 to elicit antitumor helper T cells against head and neck squamous cell carcinoma."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:23:20.510516+00:00"}