{"created":"2023-06-19T11:24:29.790624+00:00","id":5224,"links":{},"metadata":{"_buckets":{"deposit":"0acf0216-fc3c-4d82-afb1-2275b156b44e"},"_deposit":{"created_by":1,"id":"5224","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"5224"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00005224","sets":["7","7:24"]},"author_link":["16267","16265","16272","16268","16266","16271","16269","16270"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"153","bibliographicPageStart":"150","bibliographicVolumeNumber":"127","bibliographic_titles":[{"bibliographic_title":"Journal of Pharmacological Sciences"}]}]},"item_5_description_28":{"attribute_name":"識別番号 その他","attribute_value_mlt":[{"subitem_description":"PMID:25704031","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Regulation of intestinal secretion is important for body fluid homeostasis. We investigated the role of three MAP kinases (MAPKs) as negative regulators in muscarinic cholinoceptor (mAChR)-mediated intestinal secretion in mice. Electrophysiological analyses revealed that mAChR stimulation enhanced intestinal chloride secretion, which was further augmented by the inhibition of JNK but not by that of ERK or p38 with specific inhibitors SP600125, U0126 or SB203580, respectively. Immunoblot analyses in colonic mucosa showed that mAChR stimulation increased MAPKs phosphorylation that was suppressed by the specific inhibitor for each MAPK. This suggests that JNK is a major negative regulator in mAChR-induced intestinal secretion.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Open Access\nCC BY-NC-ND","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jphs.2014.10.001.","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-8613","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"25704031"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"599"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"997"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"Suzuki, Yuichi"},{"subitem_text_value":"Uwada, Junsuke"},{"subitem_text_value":"&EMPTY&"},{"subitem_text_value":"Taniguchi, Takanobu"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Md, Rafiqul Islam  Khan"}],"nameIdentifiers":[{"nameIdentifier":"16265","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Md, Tariqul  Islam"}],"nameIdentifiers":[{"nameIdentifier":"16266","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yazawa, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"16267","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayashi, Hisayoshi"}],"nameIdentifiers":[{"nameIdentifier":"16268","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木, 裕一"},{"creatorName":"スズキ, ユウイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16269","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宇和田, 淳介"},{"creatorName":"ウワダ, ジュンスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16270","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Abu, Syed Md  Anisuzzaman"}],"nameIdentifiers":[{"nameIdentifier":"16271","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"谷口, 隆信"},{"creatorName":"タニグチ, タカノブ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"16272","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"6125.pdf","filesize":[{"value":"507.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"6125.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/5224/files/6125.pdf"},"version_id":"b74fcf7f-f2be-4bbf-bb89-8893b119efe2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Intestinal secretion","subitem_subject_scheme":"Other"},{"subitem_subject":"mAChR","subitem_subject_scheme":"Other"},{"subitem_subject":"MAP kinase","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Muscarinic cholinoceptor-mediated activation of JNK negatively regulates intestinal secretion in mice.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Muscarinic cholinoceptor-mediated activation of JNK negatively regulates intestinal secretion in mice."}]},"item_type_id":"5","owner":"1","path":["6","7","24"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-05-22"},"publish_date":"2015-05-22","publish_status":"0","recid":"5224","relation_version_is_last":true,"title":["Muscarinic cholinoceptor-mediated activation of JNK negatively regulates intestinal secretion in mice."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T12:26:48.846085+00:00"}