{"created":"2023-06-19T11:24:01.263613+00:00","id":4661,"links":{},"metadata":{"_buckets":{"deposit":"a98e8eb1-018d-4536-98dc-740a25fe2057"},"_deposit":{"created_by":3,"id":"4661","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4661"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00004661","sets":["7","7:23"]},"author_link":["14428","14429","14430","14431","14432","14433","14434","14435"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"2306","bibliographicPageStart":"2304","bibliographicVolumeNumber":"101","bibliographic_titles":[{"bibliographic_title":"日本内科学会雑誌"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"53歳男。35歳頃より月に1日程度37度台の発熱と体幹・関節の疼痛および胸背部や肩関節痛が出現するようになり、続いて腹痛も出現し、発熱の頻度も週に1日程度に増加した。原因の特定のため当科を受診した。CRPの上昇と赤沈亢進以外に異常所見は認めず、周期的発熱に随伴する症状は漿膜炎症状や関節炎症状であったため、自己炎症疾患の可能性を考え遺伝子解析を実施した。家族性地中海熱(FMF)遺伝子のMEFV遺伝子exon 2および10にE148Q/M694Iの変異を認め、FMFと確定診断した。コルヒチン1mg/day内服で発熱はなくなり、体幹や関節の疼痛も消失し炎症反応の上昇も認めなくなったが、コルヒチンによると考えられる肝障害が出現した。コルヒチン1回0.5mg/を週2〜3回の内服に減量したところ、肝障害の改善を認め、発熱、体幹や関節の疼痛悪化もなく経過している。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"著者最終原稿版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_27":{"attribute_name":"医中誌ID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"2012361501","subitem_relation_type_select":"ICHUSHI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-5384","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2012361501"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2023"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1783"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Asanome, Asuka"},{"subitem_text_language":"en","subitem_text_value":"Endo, Hisako"},{"subitem_text_language":"en","subitem_text_value":"Saito, Tsukasa"},{"subitem_text_language":"en","subitem_text_value":"Katayama, Takayuki"},{"subitem_text_language":"en","subitem_text_value":"Hasebe, Naoyuki"},{"subitem_text_language":"en","subitem_text_value":"Migita, Kiyoshi"},{"subitem_text_language":"en","subitem_text_value":"Ida, Hiroaki"},{"subitem_text_language":"en"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"澤田, 潤","creatorNameLang":"ja"},{"creatorName":"サワダ, ジュン","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"14428","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"浅野目, 明日香","creatorNameLang":"ja"},{"creatorName":"アサノメ, アスカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"14429","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"遠藤, 寿子","creatorNameLang":"ja"},{"creatorName":"エンドウ, ヒサコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"14430","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"齋藤, 司","creatorNameLang":"ja"},{"creatorName":"サイトウ, ツカサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"14431","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"片山, 隆行","creatorNameLang":"ja"},{"creatorName":"カタヤマ, タカユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"14432","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷部, 直幸","creatorNameLang":"ja"},{"creatorName":"ハセベ, ナオユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"14433","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"右田, 清志","creatorNameLang":"ja"},{"creatorName":"ミギタ, キヨシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"14434","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井田, 弘明","creatorNameLang":"ja"},{"creatorName":"イダ, ヒロアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"14435","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"5470.pdf","filesize":[{"value":"249.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"5470.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/4661/files/5470.pdf"},"version_id":"8e097b86-2480-4db3-ac03-c8f2986d8c5f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"家族性地中海熱","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"自己炎症疾患","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"周期熱","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"成人","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"30代で発症した家族性地中海熱の1例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"30代で発症した家族性地中海熱の1例","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"3","path":["6","7","23"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-10-09"},"publish_date":"2013-10-09","publish_status":"0","recid":"4661","relation_version_is_last":true,"title":["30代で発症した家族性地中海熱の1例"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-07-26T09:04:56.706219+00:00"}