{"created":"2023-06-19T11:23:58.369561+00:00","id":4607,"links":{},"metadata":{"_buckets":{"deposit":"59b38e65-abb0-4635-8505-676c5e064f9d"},"_deposit":{"created_by":3,"id":"4607","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4607"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00004607","sets":["7","7:23"]},"author_link":["14255"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"785","bibliographicPageStart":"779","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"臨床病理"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The complement has been identified as a complementation factor to compensate a function of antibody. The complement consists of C1-C9, complement related molecules, and its regulating molecules. Three major biological roles in complement are classified. First is an opsonization following the phagocytosis and elimination of microbes. Second is a direct destruction of bacteria due to make membrane attack complex (MAC). Third is a complement activation following the induction of anaphylactoid factors and local recruitment and activation of neutrophilic leukocytes. In this review, I summarize the basic findings and recent treatments of paroxysmal nocturnal hemogloburinuria (PNH) and hereditary angioedema (HAE). Finally, I make a short review with a rare autosomal recessive disorder of 3MC syndrome and propose the new biological functions of complement factors except for that of innate immunity.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"著者最終原稿版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0047-1860","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"M927140009"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"683"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1038"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"若宮, 伸隆","creatorNameLang":"ja"},{"creatorName":"ワカミヤ, ノブタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"14255","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"5400.pdf","filesize":[{"value":"947.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"5400.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/4607/files/5400.pdf"},"version_id":"9223da0b-b89c-4ec9-a778-8db447667ef2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"補体","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"発作性夜間ヘモグロビン尿症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝性血管性浮腫","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"GPIアンカー型タンパク質","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"C1インヒビター","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"3MC症候群","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"補体系の役割と臨床医学でのトピックス","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"補体系の役割と臨床医学でのトピックス","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"3","path":["6","7","23"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-28"},"publish_date":"2013-08-28","publish_status":"0","recid":"4607","relation_version_is_last":true,"title":["補体系の役割と臨床医学でのトピックス"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-07-26T09:06:02.536545+00:00"}