{"created":"2023-06-19T11:23:44.648368+00:00","id":4329,"links":{},"metadata":{"_buckets":{"deposit":"16eb6408-20c5-4eb4-82da-9217532d0095"},"_deposit":{"created_by":3,"id":"4329","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4329"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00004329","sets":["7","7:19:25","7:27:41"]},"author_link":["13488","13489","13490","13491","13492","13493"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"49","bibliographicPageStart":"38","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"旭川医科大学研究フォーラム"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hyperalgesia is one of the symptoms of diabetic neuropathy, particularly in the early stages of diabetic neuropathy. The activation of neurokinin1 (NK1) receptors in the spinal cord by substance P results in thermal and mechanical hyperalgesia. The relationship between glucose and NK1 receptor expression has not been reported. We investigated the hypothesis that in the diabetic state, high glucose directly induce NK1 receptor expression in rat spinal neuronal cells. We used primary cultures of neonatal rat spinal neurons to elucidate whether NK1 receptor expression is regulated by glucose. NK1 receptor expression increased in cells cultured under a high glucose condition. Although inhibitors of protein kinase A, protein kinase C, and aldose reductase did not affect NK1 receptor expression, α-lipoic acid suppressed it under high glucose conditions. A specific inhibitor of mitochondrial complex II also suppressed the increase in NK1 receptor expression. These results indicate that high glucose increases NK1 receptor expression, which is due to oxidative stress and NK1 receptor expression contributes to mechanisms underlying hyperalgesia in diabetic neuropathy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-0102","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"f1301038"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1645"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"907"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Abiko, Atsuko"},{"subitem_text_language":"en","subitem_text_value":"Ito, Hiroshi"},{"subitem_text_language":"en","subitem_text_value":"Hirano, Fuminori"},{"subitem_text_language":"en","subitem_text_value":"Takiyama, Yumi"},{"subitem_text_language":"en","subitem_text_value":"Haneda, Masakazu"},{"subitem_text_language":"en"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石関, 哉生","creatorNameLang":"ja"},{"creatorName":"イシゼキ, カナキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"13488","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安孫子, 亜津子","creatorNameLang":"ja"},{"creatorName":"アビコ, アツコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"13489","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"伊藤, 博史","creatorNameLang":"ja"},{"creatorName":"イトウ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"13490","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野, 史倫","creatorNameLang":"ja"},{"creatorName":"ヒラノ, フミノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"13491","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"滝山, 由美","creatorNameLang":"ja"},{"creatorName":"タキヤマ, ユミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"13492","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽田, 勝計","creatorNameLang":"ja"},{"creatorName":"ハネダ, マサカズ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"13493","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"5085.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"5085.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/4329/files/5085.pdf"},"version_id":"46a41464-4467-449c-84fa-d49a5df89f22"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"diabetic neuropathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hyperalgesia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neurokinin1 receptors","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oxidative stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"培養ラット脊髄神経細胞における高濃度ブドウ糖によるニューロキニン１受容体の発現亢進","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"培養ラット脊髄神経細胞における高濃度ブドウ糖によるニューロキニン１受容体の発現亢進","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"3","path":["6","7","25","41"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-03-14"},"publish_date":"2013-03-14","publish_status":"0","recid":"4329","relation_version_is_last":true,"title":["培養ラット脊髄神経細胞における高濃度ブドウ糖によるニューロキニン１受容体の発現亢進"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-07-26T08:46:28.578015+00:00"}