{"created":"2023-06-19T11:23:43.285073+00:00","id":4301,"links":{},"metadata":{"_buckets":{"deposit":"8b2e40a6-9d19-427f-9daa-0d129e2a826b"},"_deposit":{"created_by":3,"id":"4301","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4301"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00004301","sets":["7","7:23"]},"author_link":["13364","13365","13366","13367"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"382","bibliographicPageStart":"375","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"分子消化器病"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"腸管は解剖学的に脂肪組織に接していることから、腸管および脂肪組織の生理機能調節やさまざまな病態において、腸管と脂肪組織間に相互作用の存在が示唆されている。本稿では、まずそのような相互作用を示唆する報告として、消化管ホルモンであるgastric inhibitory polypeptideの作用、クローン病(Crohn's disease:CD)における脂肪組織の肥厚、アディポサイトカインの関与などを例にあげ概説した。つぎに脂肪細胞や腸管などに発現し、脂質代謝調節、脂肪細胞分化、転写調節など多彩な作用をもつ分子であるlipinについて解説した。最後に、最近われわれがおこなった、肥満の病態におけるlipinの関与に関して、その解析法を含めて紹介した。今後、腸管と脂肪組織の相互作用は、代謝、炎症、腫瘍などさまざまな病態において重要なテーマになるものと思われる。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348-995X","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2010065854"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"710"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"546"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Tsuchiya, Yoshihiro"},{"subitem_text_language":"en","subitem_text_value":"Fujiya, Mikihiro"},{"subitem_text_language":"en","subitem_text_value":"Kohgo, Yutaka"},{"subitem_text_language":"en"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高橋, 伸彦","creatorNameLang":"ja"},{"creatorName":"タカハシ, ノブヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"13364","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"土屋, 慶容","creatorNameLang":"ja"},{"creatorName":"ツチヤ, ヨシヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"13365","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"藤谷, 幹浩","creatorNameLang":"ja"},{"creatorName":"フジヤ, ミキヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"13366","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高後, 裕","creatorNameLang":"ja"},{"creatorName":"コウゴ, ユタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"13367","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"5055.pdf","filesize":[{"value":"6.4 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