{"created":"2023-06-19T11:23:38.109160+00:00","id":4202,"links":{},"metadata":{"_buckets":{"deposit":"848aaf13-78a1-4c26-aaa4-f856522b9152"},"_deposit":{"created_by":3,"id":"4202","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4202"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00004202","sets":["7","7:23"]},"author_link":["12887","12888","12889","12890"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"39","bibliographicPageStart":"33","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"分子消化器病"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"小胞体ストレスとは、さまざまな生理的な条件下で小胞体の蛋白フォールディングが障害される状態であり、小胞体ストレス応答(UPR)とよばれる複雑なシグナル伝達系が誘導される。ストレスに対する細胞の適応現象と考えられるが、UPRで十分に適応できないときには小胞体ごと除去するオートファジーの機構がはたらく。それらでも十分な効果を示さないときにはアポトーシスやオートファジー細胞死により、最終的に異常な細胞は駆除されている。最近では、腫瘍細胞が発生や増殖の段階で、UPRやそれにつづくオートファジーを利用していることが明らかにされてきた。さらに、治療のターゲットとしての研究が進められている。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348-995X","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2012166926"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1731"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"790"}]},"item_5_text_7":{"attribute_name":"著者 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小胞体ストレス誘導性オートファジーの制御による治療の可能性を探る","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"【消化器癌治療における新しい分子標的】 小胞体ストレス誘導性オートファジーの制御による治療の可能性を探る","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"3","path":["6","7","23"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-11-16"},"publish_date":"2012-11-16","publish_status":"0","recid":"4202","relation_version_is_last":true,"title":["【消化器癌治療における新しい分子標的】 小胞体ストレス誘導性オートファジーの制御による治療の可能性を探る"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-07-26T08:56:39.733794+00:00"}