{"created":"2023-06-19T11:23:34.843033+00:00","id":4143,"links":{},"metadata":{"_buckets":{"deposit":"29707bfa-4842-480a-ac9a-08ce279d2081"},"_deposit":{"created_by":3,"id":"4143","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4143"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00004143","sets":["7","7:23"]},"author_link":["12660","12661","12662","12663","12664"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1993-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"2684","bibliographicPageStart":"2679","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"薬理と治療"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"2型高脂血症患者37名に,HMG-CoA還元酵素阻害剤の一つであるシンバスタチンを5mg/day,12週間投与した。1)総コレステロールとLDL-コレステロールは2週目より安定した有意な低下を示し,12週後の低下率はそれぞれ24.3%と34.8%であった。中性脂肪においても有意な低下を示し,その低下率は17.5%であった。HDL-コレステロールは12週目で有意な上昇(5.6%)を示した。さらに動脈硬化指数には安定した低下が観察され,その低下率は33.5%を示した。2)アポ蛋白A-1には有意な変動はみなかったが,アポ蛋白B,アポ蛋白Eを有意に減少させた。3)Lipoprotein(a)には有意な変動をみなかった。4)CPKの高値を認めたが,正常上限の2倍程度であり,中止に至る症例はなかった。以上より,本剤は高脂血症に対する高い臨床的有用性と安全性を示した","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-3603","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1994069110"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"799"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"364"}]},"item_5_text_7":{"attribute_name":"著者 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