{"created":"2023-06-19T11:23:30.250908+00:00","id":4057,"links":{},"metadata":{"_buckets":{"deposit":"2f04c0a6-9551-49a5-92ef-9eefd37d7903"},"_deposit":{"created_by":3,"id":"4057","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4057"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00004057","sets":["7","7:23"]},"author_link":["12383"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"90","bibliographicPageStart":"87","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"口腔・咽頭科"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"IgA腎症における扁桃摘出術(+ステロイドパルス療法)の有効性は全国的に浸透しているが、扁桃とIgA腎症の関係を証明する基礎的な背景は十分に理解されていない。これまでの検討結果から、IgA腎症扁桃がIgAを過剰産生し、病因となる血中IgAの供給源となっていることは間違いない。我々の研究結果から、細菌由来DNAへの過剰応答によるIFN-γやBAFF(B cell activating factor)の産生上昇が扁桃B細胞からのIgA過剰産生の要因となっている可能性が示唆された。さらに、ケモカイン・ケモカインレセプターを介したTCR Vβ6、CXCR3陽性扁桃T細胞の腎へのホーミングが病因に関与している可能性が示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"著者最終原稿版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0917-5105","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2011187208"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"649"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"206"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高原, 幹","creatorNameLang":"ja"},{"creatorName":"タカハラ, ミキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"12383","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"4771.pdf","filesize":[{"value":"397.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"4771.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/4057/files/4771.pdf"},"version_id":"05566184-fb60-401d-b822-b59af77ecfdb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"IgA腎症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"扁桃摘出術","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"BAFF(B cell activating factor)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TCR Vβ6","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CXCR3","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"扁桃病巣感染症研究の最前線 IgA腎症扁桃におけるIgA過剰産生とT細胞の関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"扁桃病巣感染症研究の最前線 IgA腎症扁桃におけるIgA過剰産生とT細胞の関与","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"3","path":["6","7","23"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-08-29"},"publish_date":"2012-08-29","publish_status":"0","recid":"4057","relation_version_is_last":true,"title":["扁桃病巣感染症研究の最前線 IgA腎症扁桃におけるIgA過剰産生とT細胞の関与"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-07-26T09:05:13.742305+00:00"}