{"created":"2023-06-19T11:23:28.362538+00:00","id":4016,"links":{},"metadata":{"_buckets":{"deposit":"0c83f68e-333f-4119-8f99-bf8e0be35624"},"_deposit":{"created_by":3,"id":"4016","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"4016"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00004016","sets":["7","7:24"]},"author_link":["12150","12151","12152","12153","12154","12155","12156","12157","12158","12159"],"control_number":"4016","item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"418481-8","bibliographicPageStart":"418481-1","bibliographicVolumeNumber":"2011","bibliographic_titles":[{"bibliographic_title":"Evidence-based Complementary and Alternative Medicine"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"Copyright &#169; 2011 Toru Kono et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | Copyright &#169; 2011 Toru Kono et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Peripheral neurotoxicity is the major limiting factor for oxaliplatin therapy. Goshajinkigan (GJG), a traditional Japanese herbal medicine, was recently shown to be effective in protecting against the neurotoxicity of taxanes in Japan. We retrospectively investigated the effect of GJG on peripheral neurotoxicity associated with oxaliplatin therapy. Ninety patients with metastatic colorectal cancer that received FOLFOX4 or modified FOLFOX6 therapy were assigned to receive one of the following adjuncts: oral GJG at 7.5 g day^<−1> (Group A, n = 11), intravenous supplementation of calcium gluconate and magnesium sulfate (1 g each before and after FOLFOX) (Group B, n = 14), combined GJG and calcium gluconate and magnesium sulfate therapies (Group C, n = 21), or no concomitant therapy (Group D, n = 44). The incidence of peripheral neurotoxicity was investigated when the cumulative dose of oxaliplatin exceeded 500 mgm^<−2>.When the cumulative dose of oxaliplatin exceeded 500 mgm^<−2>, the incidence of neuropathy (all grades) in Groups A-Dwas 50.0%, 100%, 78.9%, and 91.7%, respectively. It was lowest in the group that received GJG alone. Concomitant administration of GJG reduced the neurotoxicity of oxaliplatin in patients that received chemotherapy for colorectal cancer.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"http://creativecommons.org/licenses/by/3.0/","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/ecam/nep200","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1741-427X","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"19952054"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1245"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"952"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河野, 透","creatorNameLang":"ja"},{"creatorName":"コウノ, トオル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"12150","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mamiya, Noriaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12151","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chisato, Naoyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12152","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ebisawa, Yosiaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12153","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamazaki, Hirotaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12154","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watari, Jiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12155","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Yasuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12156","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Shigetaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12157","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Asama, Toshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12158","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamiya, Kazunori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"12159","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"4488.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"4488.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/4016/files/4488.pdf"},"version_id":"8fa7f488-9d20-4053-9aca-b223867e2255"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Efficacy of Goshajinkigan for Peripheral Neurotoxicity of Oxaliplatin in Patients with Advanced or Recurrent Colorectal Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Efficacy of Goshajinkigan for Peripheral Neurotoxicity of Oxaliplatin in Patients with Advanced or Recurrent Colorectal Cancer","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-05-17"},"publish_date":"2012-05-17","publish_status":"0","recid":"4016","relation_version_is_last":true,"title":["Efficacy of Goshajinkigan for Peripheral Neurotoxicity of Oxaliplatin in Patients with Advanced or Recurrent Colorectal Cancer"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-07-31T04:30:26.580948+00:00"}