{"created":"2023-06-19T11:23:22.132894+00:00","id":3891,"links":{},"metadata":{"_buckets":{"deposit":"3737b0b8-0f6b-4298-9a0c-ef8febf8b014"},"_deposit":{"created_by":3,"id":"3891","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3891"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00003891","sets":["7","7:23"]},"author_link":["11704","11705","11706","11707"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"169","bibliographicPageStart":"168","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"耳鼻咽喉科免疫アレルギー"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"由来の違う2種類の鼻性NK/T細胞リンパ腫細胞株SNK6,SNT8,NK細胞リンパ腫細胞株NK92及び健常人より分離した正常末梢血リンパ球(PBMC)を用いてcDNA arrayを行い,PBMC,NK92とSNK6,SNT8間で発現差のある遺伝子をスクリーニングし,SNK6,SNT8両細胞株間で共通して発現上昇の見られた遺伝子を検出した.発現上昇が認められた遺伝子の一つにIL-9が存在した.SNK6,SNT8,PBMC及び他のリンパ腫・白血病細胞株間でIL-9及びIL-9RのmRNAレベルでの発現の差を比較検討し,更に臨床検体におけるIL-9の免疫染色を行った.IL-9はPBMCと比較するとSNK6で3.88倍,SNT8で19.3倍の発現上昇を認め,NK92との比較ではSNK6で3.57倍,SNT8で29.6倍の発現上昇が認められた.IL-9はSNK6及びSNT8のみに発現が認められた.IL-9RはPBMC以外の全細胞株で発現が認められた.IL-2RγはPBMC及び全細胞株で発現が認められた.免疫染色は13例中8例で陽性であった","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載版 著作権は学会に属す","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0913-0691","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2004038862"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"713"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"234"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Kishibe, Kan"},{"subitem_text_language":"en","subitem_text_value":"Takahara, Miki"},{"subitem_text_language":"en","subitem_text_value":"Harabuchi ,Yasuaki"},{"subitem_text_language":"en"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長門, 利純","creatorNameLang":"ja"},{"creatorName":"ナガト, トシヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"11704","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岸部, 幹","creatorNameLang":"ja"},{"creatorName":"キシベ, カン","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"11705","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高原, 幹","creatorNameLang":"ja"},{"creatorName":"タカハラ, ミキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"11706","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原渕, 保明","creatorNameLang":"ja"},{"creatorName":"ハラブチ, ヤスアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"11707","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"4606.pdf","filesize":[{"value":"343.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"4606.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/3891/files/4606.pdf"},"version_id":"b4e743e6-976a-46eb-81b3-afcdfd78dcf0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"鼻性NK/T細胞リンパ腫におけるIL-9の発現","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"鼻性NK/T細胞リンパ腫におけるIL-9の発現","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"3","path":["6","7","23"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-06-14"},"publish_date":"2012-06-14","publish_status":"0","recid":"3891","relation_version_is_last":true,"title":["鼻性NK/T細胞リンパ腫におけるIL-9の発現"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-07-26T09:03:56.457095+00:00"}