{"created":"2023-06-19T11:23:20.309194+00:00","id":3856,"links":{},"metadata":{"_buckets":{"deposit":"40579ec7-66a9-4cdb-bf4c-8e9bbb8a93ae"},"_deposit":{"created_by":3,"id":"3856","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3856"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00003856","sets":["7","7:23"]},"author_link":["11512","11513"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"812","bibliographicPageStart":"808","bibliographicVolumeNumber":"69","bibliographic_titles":[{"bibliographic_title":"日本臨床"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Incretins, such as GIP and GLP-1 enhance insulin secretion from pancreatic β cells in a glucose dependent manner. Incretins potentiate adenylate cyclase activity trough their G-protein coupled receptors and then increase intracellular cAMP level. Intracellular cAMP modulates insulin secretion by both PKA-dependent and PKA-independent pathways. PKA potentiates intracellular Ca+ influx via phosphorylation of voltage dependent calcium channel (VDCC), which increases insulin exocyosis. PKA also phosphorylates KATP channel and facilitates insulin release. In contrast, Epac2 potentiates insulin secretion by cAMP in a PKA–independent pathway. The small G-protein Rap1, which is activated specifically through Epac2, contributes the first phase of insulin secretion possibly by control of insulin granules fusion to plasma membrane.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"著者最終原稿版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0047-1852","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2011212537"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1229"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"3151"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Haneda, Masakazu"},{"subitem_text_language":"en"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤田, 征弘","creatorNameLang":"ja"},{"creatorName":"フジタ, ユキヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"11512","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽田, 勝計","creatorNameLang":"ja"},{"creatorName":"ハネダ, マサカズ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"11513","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"4566.pdf","filesize":[{"value":"563.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"4566.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/3856/files/4566.pdf"},"version_id":"3f6cde37-e189-4d0b-a8b4-95c49d9d9b67"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cAMP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PKA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Epac2","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"【インクレチン関連薬　糖尿病治療のパラダイムシフト】 インクレチンの基礎・臨床研究の進歩　インクレチンのインスリン分泌促進作用の分子メカニズム","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"【インクレチン関連薬　糖尿病治療のパラダイムシフト】 インクレチンの基礎・臨床研究の進歩　インクレチンのインスリン分泌促進作用の分子メカニズム","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"3","path":["6","7","23"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-05-24"},"publish_date":"2012-05-24","publish_status":"0","recid":"3856","relation_version_is_last":true,"title":["【インクレチン関連薬　糖尿病治療のパラダイムシフト】 インクレチンの基礎・臨床研究の進歩　インクレチンのインスリン分泌促進作用の分子メカニズム"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-07-26T09:05:18.621731+00:00"}