{"created":"2023-06-19T11:23:14.584148+00:00","id":3739,"links":{},"metadata":{"_buckets":{"deposit":"399d92ac-04f7-4f3b-940f-3ac852cc4a19"},"_deposit":{"created_by":1,"id":"3739","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"3739"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00003739","sets":["7","7:23"]},"author_link":["11055","11058","11061","11059","11056","11057","11060"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1982-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"438","bibliographicPageStart":"433","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"臨床薬理"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ラットの拘束水浸ストレス潰瘍の発生実験におけるCS-386の抑制効果につき検討した.1) CS-386 10 mg/kg, 30 mg/kg, 50 mg/kg, 100 mg/kg,いずれの投与量においても有意にストレス潰瘍の発生を抑制した.抑制率はそれぞれ46.8%,51.5%,62.6%,70.3%であった.2)ストレス潰瘍の組織学的にみた深さの検討では,変化が粘膜筋板をこえるものはなく,すべてエロジオンであり,コントロールとCS-386群とで差は認められなかった.3)血中ガストリン値はストレス付加後に上昇するが,CS-386投与群では30, 100 mg/kg群に有意の上昇抑制がみられた.Diazepamでも同様有意に抑制された.4)投与時間の違いによる検討では,ストレス負荷直前投与が,30 min前,60 min前投与よりも抑制効果が強かった.5)胃粘膜の経時的内視鏡観察では,コントロール群5匹中1匹にストレス負荷1 hr後に出血性エロジオンの出現をみ,CS-386投与群では5匹中1匹に3 hr後に出血性エロジオンがあらわれ,他の8匹ではすべて2 hr後に出現していた.6) Diazepamも明らかにストレス潰瘍の発生を抑制したが,CS-386のほうが抑制率はやや高い傾向を示した.しかし有意の差はなかった","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"雑誌掲載版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0388-1601","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1983150082"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"360"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Mizushima, Kazuo"},{"subitem_text_value":"Shibata, Yoshimi"},{"subitem_text_value":"Hayashi, Norio"},{"subitem_text_value":"Kitagawa, Takashi"},{"subitem_text_value":"Harada, Kazumichi"},{"subitem_text_value":"Okamura, Kiyoshi"},{"subitem_text_value":"Namiki, Masayoshi"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"水島, 和雄"},{"creatorName":"ミズシマ, カズオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"柴田, 好"},{"creatorName":"シバタ, ヨシミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"林, 憲雄"},{"creatorName":"ハヤシ, ノリオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"北川, 隆"},{"creatorName":"キタガワ, タカシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"原田, 一道"},{"creatorName":"ハラダ, カズミチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岡村, 毅興志"},{"creatorName":"オカムラ, キヨシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"並木, 正義"},{"creatorName":"ナミキ, マサヨシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"4290.pdf","filesize":[{"value":"7.7 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