{"created":"2023-06-19T11:23:12.790752+00:00","id":3703,"links":{},"metadata":{"_buckets":{"deposit":"47dd56c5-bfbf-4dfa-958c-40330dee2d7d"},"_deposit":{"created_by":3,"id":"3703","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3703"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00003703","sets":["7","7:23"]},"author_link":["10907","10908"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"128","bibliographicPageStart":"124","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"血圧"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"糖尿病性腎症の成因は、高血糖と糸球体高血圧である。高血糖により生じる細胞内生化学的異常である、(1)ポリオール経路の亢進、(2)ヘキソサミン経路の亢進、(3)プロテインキナーゼ(protein kinase C:PKC)活性化、(4)酸化ストレス、(5)終末糖化産物(advanced glycation end products:AGEs)の蓄積、(6)epigenetic mechanismは、腎臓に機能的および組織学的異常を惹起する。さらにレニン・アンジオテンシン・アルドステロン(RAA)系の亢進は、糸球体高血圧、腎線維化を引き起こす。これら病態にもとづいた血糖コントロールとRAA系抑制薬による糖尿病性腎症への腎保護作用は明らかである","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1340-4598","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2011129125"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1043"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"936"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Haneda, Masakazu"},{"subitem_text_language":"en"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"滝山, 由美","creatorNameLang":"ja"},{"creatorName":"タキヤマ, ユミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"10907","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"羽田, 勝計","creatorNameLang":"ja"},{"creatorName":"ハネダ, マサカズ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"10908","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"4251.pdf","filesize":[{"value":"4.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"4251.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/3703/files/4251.pdf"},"version_id":"9f32d818-43c6-43ed-8fcb-f283fb7a467e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"糖尿病性腎症","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"高血糖","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"糸球体高血圧","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"RAA系","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"【糖尿病性細小血管障害と高血圧】 糖尿病性腎症の病態","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"【糖尿病性細小血管障害と高血圧】 糖尿病性腎症の病態","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"3","path":["6","7","23"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2012-02-07"},"publish_date":"2012-02-07","publish_status":"0","recid":"3703","relation_version_is_last":true,"title":["【糖尿病性細小血管障害と高血圧】 糖尿病性腎症の病態"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-07-26T09:00:12.089724+00:00"}