{"created":"2023-06-19T11:23:10.453260+00:00","id":3658,"links":{},"metadata":{"_buckets":{"deposit":"b9f00c06-b3e9-4f98-9a83-ffc83bb6de36"},"_deposit":{"created_by":3,"id":"3658","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3658"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00003658","sets":["7","7:23"]},"author_link":["10696","10697","10698","10699","10700","10701","10702","10703"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Suppl.2","bibliographicPageEnd":"S154","bibliographicPageStart":"S151","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"薬理と治療"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"非ステロイド性抗炎症薬(NSAIDs)を用い内因性prostaglandin(PG)系のconcanavalin A(Con A)肝障害モデルに対する関与とCon A投与後のサイトカイン・ケモカイン産生能に対する影響について検討した.7週齢の雌性BALB/cマウスにCon A 15mg/kgを尾静脈から投与して肝障害モデルを作製し,NSAIDsとしてindomethacinを5mg/kgをCon A投与30分後に腹腔内投与した.Con A投与2,4,8,24時間後の血中ALT・TNF-α・IFN-γ・MIP-2値,prostacyclinの安定代謝物の6-keto-PG-F1α値を測定した.その結果,NSAIDsの投与によりCon A投与後血中6-keto-PG-F1α値は対照群に比べ有意に低下し,Con A投与血中ALT値は対照群に比べ有意に上昇した.NSAIDs前投与によりCon A投与後の血中TNF-αは変化を認めなかったが,IFN-γ値・MIP-2値はCon A投与後に有意に高値を示した.以上より,Con A肝障害モデルは肝細胞障害発症機序と治療法検討に有用であるものと考えられた","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0386-3603","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2005119402"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1688"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"508"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Tamaki, Yosui"},{"subitem_text_language":"en","subitem_text_value":"Yokohama, Shiro"},{"subitem_text_language":"en","subitem_text_value":"Okada, Mitsuyoshi"},{"subitem_text_language":"en","subitem_text_value":"Aso, Kazunobu"},{"subitem_text_language":"en","subitem_text_value":"Nakamura, Kimihide"},{"subitem_text_language":"en","subitem_text_value":"Haneda, Masakazu"},{"subitem_text_language":"en","subitem_text_value":"Yoneda, Masashi"},{"subitem_text_language":"en"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡本, 聡","creatorNameLang":"ja"},{"creatorName":"オカモト, 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