{"created":"2023-06-19T11:23:09.320406+00:00","id":3636,"links":{},"metadata":{"_buckets":{"deposit":"fb8404b0-743e-478c-9ba7-a336816f9085"},"_deposit":{"created_by":3,"id":"3636","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3636"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00003636","sets":["7","7:23"]},"author_link":["10574"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"275","bibliographicPageStart":"268","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"G.I.Research"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"漢方は日本の伝統的医学であり、西洋医学と同等に使用できる唯一の医療先進国である。消化器外科領域を中心に大建中湯は臨床で高い実績と信用を得た漢方薬でありながら、薬効発現の本質的な機序が不明であった。大建中湯の腸管血流増加作用を実験的に検証した結果、大建中湯の主要生薬である山椒の主成分hydroxy-α-sanshool、乾姜の主成分6-shogaolが腸管粘膜に作用し神経終末から神経ペプチドcalcitonin gene-related peptide、腸管上皮細胞からアドレノメデュリンという2つの強力な微小血管拡張作用を有するカルシトニンファミリーペプチドを介して作用を発現し、さらに受容体関連因子をも増強させることで腸管血流を増加させることを概説した。また、血流低下が病因論的に関与しているクローン病への大建中湯の応用も、血流改善だけでなくカルシトニンファミリーペプチドによる抗TNF-α抑制効果からその可能性について言及した。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0918-9408","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2010290445"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1264"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1680"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河野, 透","creatorNameLang":"ja"},{"creatorName":"コウノ, トオル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"10574","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"4175.pdf","filesize":[{"value":"10.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"4175.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/3636/files/4175.pdf"},"version_id":"7108ed86-3adf-464f-a0b4-629becf1c1c6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"大建中湯","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"カルシトニン遺伝子関連ペプチド（CGRP）","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"アドレノメデュリン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"hydoroxy-α-sanshool","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"6-shogaol","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"【消化器疾患と漢方】 消化管血流と漢方","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"【消化器疾患と漢方】 消化管血流と漢方","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"3","path":["6","7","23"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-12-26"},"publish_date":"2011-12-26","publish_status":"0","recid":"3636","relation_version_is_last":true,"title":["【消化器疾患と漢方】 消化管血流と漢方"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-07-26T08:53:31.219111+00:00"}