{"created":"2023-06-19T11:23:04.645439+00:00","id":3551,"links":{},"metadata":{"_buckets":{"deposit":"7611a34d-4934-478e-b9f0-99d550d4f810"},"_deposit":{"created_by":3,"id":"3551","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3551"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00003551","sets":["7","7:23"]},"author_link":["10188","10189","10190","10191","10192"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"475","bibliographicPageStart":"469","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"自律神経"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"in vivoの実験では右心房内へカテーテルを慢性的に留置したWistar系雄ラットを,in vitroでは下垂体単層培養法を用いた.IL-1分泌量はヒト末梢血単核球培養法を用いた.1) IL-1の静注により血中ACTH値は有意に上昇し,ピーク値は投与10分後に見られた.2) IL-1は下垂体培養細胞からのACTH分泌には影響を与えなかった.3)次に,IL-1によるACTH上昇反応が視床下部のCRFを介していることを確かめるために,CRF抗体を用いた免疫中和実験を行った.CRF抗体で前処置された群ではIL-1静注による血中ACTH反応は観察されなかった.4)プレドニソロンはヒト末梢血単核球からのIL-1分泌を用量反応性に抑制した.IL-1とH-P-A系との間に負のフィードバック調節機構の存在が示唆された","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0288-9250","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1991087113"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1111"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"460"}]},"item_5_text_7":{"attribute_name":"著者 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