{"created":"2023-06-19T11:23:04.005510+00:00","id":3540,"links":{},"metadata":{"_buckets":{"deposit":"377d5156-728e-4c2a-b2e3-267450f27dcd"},"_deposit":{"created_by":3,"id":"3540","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3540"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00003540","sets":["7","7:23"]},"author_link":["10135","10136","10137","10138","10139","10140","10141","10142","10143"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"32","bibliographicPageStart":"27","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"胆と膵"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"胆嚢癌高危険因子である合流異常において,胆嚢粘膜過形成の発生時期と胆嚢癌発生への関与について明らかにするため,小児例と成人例の合流異常を対象に分子生物学的変化を検討した.胆嚢粘膜過形成を小児例7/11,成人例38/48に認めた.小児・成人例のいずれにおいても胆嚢粘膜過形成の細胞増殖能は正常胆嚢粘膜に比べて有意に高かった.K-ras遺伝子変異は小児例では検出されず,成人例の胆嚢癌周囲の高度過形成で認められた.p53蛋白過剰発現は,胆嚢癌で認められたが,小児・成人例の胆嚢粘膜過形成では検出されなかった.合流異常では細胞増殖能の亢進した胆嚢粘膜過形成が出生時から高率に存在し,逆流膵液と胆汁との混和によって生成された変異原物質に数十年間持続的に曝され,遺伝子変化を起こしやすい病態を生じることによって,胆嚢癌発生に深く関与すると考えられる","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"著者最終原稿版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0388-9408","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2004244357"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1111"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"527"}]},"item_5_text_7":{"attribute_name":"著者 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