{"created":"2023-06-19T11:23:03.866104+00:00","id":3537,"links":{},"metadata":{"_buckets":{"deposit":"f63ae315-5267-42aa-90d6-a87f8c248b3b"},"_deposit":{"created_by":3,"id":"3537","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3537"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00003537","sets":["7","7:23"]},"author_link":["10105","10106"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"155","bibliographicPageStart":"151","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"分子消化器病"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"多くの抗癌剤は癌細胞におもにアポトーシスを誘導することでその作用を発揮する。抗癌剤によって誘導されるアポトーシスの多くはカスパーゼ経路を介することが報告されており、ミトコンドリアやデスレセプターを介するシグナルがカスパーゼ経路の活性化に関与している。さらに、さまざまなキナーゼによるシグナル伝達経路の活性化が抗癌剤によるアポトーシスの制御に重要な役割を果たしており、とくにストレス応答キナーゼであるp38 MAPKを介する経路の活性化は、抗癌剤による細胞の損傷をアポトーシスシグナルへと変換し、アポトーシス誘導過程において重要であることが明らかになってきた。抗癌剤がアポトーシスを誘導する分子機構を解明することは、抗癌剤の効果増強や副作用の軽減、分子標的薬などの新規薬剤開発にも役立つものと期待される。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348-995X","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2008229109"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"786"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"738"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Kohgo, Yutaka"},{"subitem_text_language":"en"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"丹野, 誠志","creatorNameLang":"ja"},{"creatorName":"タンノ, サトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"10105","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高後, 裕","creatorNameLang":"ja"},{"creatorName":"コウゴ, ユタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"10106","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"4063.pdf","filesize":[{"value":"9.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"4063.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/3537/files/4063.pdf"},"version_id":"26ca722d-a2ac-4056-aaf5-1d20f6936e42"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"抗癌剤","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"膵癌","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ストレス応答キナーゼ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"p38 MAPK","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"【消化器疾患におけるアポトーシスを見直す】 抗癌剤はどのような分子機構を介してアポトーシスを誘導するのか?","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"【消化器疾患におけるアポトーシスを見直す】 抗癌剤はどのような分子機構を介してアポトーシスを誘導するのか?","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"3","path":["6","7","23"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-10-24"},"publish_date":"2011-10-24","publish_status":"0","recid":"3537","relation_version_is_last":true,"title":["【消化器疾患におけるアポトーシスを見直す】 抗癌剤はどのような分子機構を介してアポトーシスを誘導するのか?"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-07-26T08:59:02.825793+00:00"}