{"created":"2023-06-19T11:23:03.775139+00:00","id":3535,"links":{},"metadata":{"_buckets":{"deposit":"1113b873-7964-402e-999c-06f392758b72"},"_deposit":{"created_by":3,"id":"3535","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3535"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00003535","sets":["7","7:23"]},"author_link":["10092","10093","10094","10095","10096","10097","10098","10099","10100","10101"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"303","bibliographicPageStart":"298","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"血圧"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"心筋培養において,AII刺激は蛋白合成速度を亢進させ,RNA/DNA比,蛋白/DNA比を増加させた.Lovastatinの前処置は,AII刺激によるこれらの増加を部分的に抑制し,これらの抑制効果はmevalonateを同時に前処理すると消失した.Lovastatin又はcalphostin Cの単独投与では,AII刺激によるMAPキナーゼ活性の亢進を各々部分的に抑制し,両者の併用は完全に抑制した.AII刺激はRas蛋白質活性を亢進させ,lovastatinはこの亢進を抑制した.以上より,HMG-CoA還元酵素阻害薬lovastatinはRas/MAPキナーゼ系を介してAII刺激時の心肥大形成を部分的に抑制すること,更にこのAII刺激時の心肥大形成にはPKC/MAPキナーゼ系に加えRas/MAPキナーゼ系が協調して関与していることが明示された","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1340-4598","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1998163396"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1121"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"757"}]},"item_5_text_7":{"attribute_name":"著者 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