{"created":"2023-06-19T11:23:01.425376+00:00","id":3488,"links":{},"metadata":{"_buckets":{"deposit":"831c5c3b-7454-46f9-a293-a4fcac4fb5a4"},"_deposit":{"created_by":3,"id":"3488","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3488"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00003488","sets":["7","7:23"]},"author_link":["9771","9772"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-09-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"288","bibliographicPageStart":"280","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"分子消化器病"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"主な有機カチオントランスポーターには、OCTファミリーとOCTNファミリーがあり、前者はおもに腎臓や肝臓に、後者は腎臓、小腸、骨格筋、脳、肺などに広く分布している。これらトランスポーターの役割は栄養素や薬剤、内因性物質の輸送にあるとされ、消化器疾患とのかかわりはあまり知られていなかった。しかし最近、MDR1やOCTN1/2に炎症性腸疾患高感受性の遺伝子多型が発見され、消化器疾患とトランスポーターとのかかわりが注目されるようになった。われわれは、腸管上皮細胞膜に存在するOCTN2がB.subtilis由来ペプチドcompetence and sporulation factor(CSF)\"を細胞内に輸送すること、それによって細胞防御蛋白であるHspが誘導され、酸化ストレスに対する抵抗性が飛躍的に向上することを見出した。これは、レセプターを介した細菌認識機構とは異なる、新しい宿主-腸内細菌の相互作用機構と考えられる。本稿では、一連の研究で用いた有機カチオントランスポーターの解析法とその輸送物質の同定法について解説した。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載版","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348-995X","subitem_source_identifier_type":"PISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2008321766"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1481"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"684"}]},"item_5_text_7":{"attribute_name":"著者 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transporter(OCTN)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"プロバイオティクス","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"B.subtilis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"competence and sporulation factor(CSF)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"腸管保護作用","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal 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