{"created":"2023-06-19T11:20:19.429308+00:00","id":346,"links":{},"metadata":{"_buckets":{"deposit":"c099f95e-0b00-49b2-8c02-d323aea89d27"},"_deposit":{"created_by":3,"id":"346","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"346"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00000346","sets":["7","7:24"]},"author_link":["741"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"8","bibliographicPageStart":"3","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"Journal of Dermatological Science"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://www.sciencedirect.com/science/journal/09231811 | http://www.sciencedirect.com/science/journal/09231811","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Loricrin is the major protein of the cornified cell envelope, a structure that replaces the plasma membrane during keratinocyte terminal differentiation. Recently, unique heterozygous, insertion mutations in the loricrin gene have been found to underlie certain congenital skin abnormalities, the phenotypes of which vary considerably. Clinically, these patients can be diagnosed as suffering from an ichthyotic variant of Vohwinkel's syndrome, progressive symmetric erythrokeratoderma, or congenital ichthyosiform erythroderma born as a collodion baby. Common clinical features include hyperkeratosis of the palms and soles with digital constriction. Histologic characteristics are parakeratotic hyperkeratosis with hypergranulosis and nuclear accumulation of mutant loricrin. The unique mutations in the glycine rich domain of the mutant loricrin form arginine rich nuclear localization sequences that disrupts differentiation of keratinocytes. This group of unique genodermatoses caused by distinct loricrin mutations is collectively termed loricrin keratoderma.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"Elsevier Science Ireland Ltd., Akemi Ishida-Yamamoto, Journal of Dermatological Science, 31(1), 2003, 3-8.\n\\nauthor","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/S0923-1811(02)00143-3","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0923-1811","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"12615358"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2369"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1159"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Yamamoto(Ishida), Akemi"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山本, 明美"},{"creatorName":"ヤマモト（イシダ）, アケミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"741","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"436.pdf","filesize":[{"value":"584.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"436.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/346/files/436.pdf"},"version_id":"5a5e59dd-4832-4eb6-abc1-82b39b8b8c66"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Loricrin keratoderma: a novel disease entity characterized by nuclear accumulation of mutant loricrin","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Loricrin keratoderma: a novel disease entity characterized by nuclear accumulation of mutant loricrin","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["6","7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2007-04-12"},"publish_date":"2007-04-12","publish_status":"0","recid":"346","relation_version_is_last":true,"title":["Loricrin keratoderma: a novel disease entity characterized by nuclear accumulation of mutant loricrin"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-19T11:42:26.910047+00:00"}