| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-03-22 |
| タイトル |
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|
タイトル |
Basophilic cytoplasmic inclusions in a case of sporadic juvenile amyotrophic lateral sclerosis |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
相澤, 仁志
Kimura, T
Kimura, T
Hashimoto, K
Yahara, O
Okamoto, K
Kikuchi, K
|
| 著者 ローマ字 |
|
|
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Aizawa, Hitoshi |
| 書誌情報 |
JOURNAL OF THE NEUROLOGICAL SCIENCES
巻 176,
号 2,
p. 109-113,
発行日 2000-06-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0022-510X |
| DOI |
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関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1016/S0022-510X(00)00321-X |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
http://www.sciencedirect.com/science/journal/0022510X | http://www.sciencedirect.com/science/journal/0022510X |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
A 24-year-old woman presented with progressive muscle atrophy and weakness of the right upper extremity. Subsequently her weakness rapidly extended to the left upper extremity, neck and lower extremities. Neurological examination disclosed involvement of the lower motor neuron system. She died 7 months after the onset. There were neuronal loss and reactive gliosis in the anterior horns of the spinal cord and much less frequently in the motor cortex. Basophilic cytoplasmic inclusions were observed in the thalamus and brain stem as well as the upper and lower motor neurons. Ultrastructurally, the inclusions lacked a limiting membrane and consisted of a meshwork of filamentous structures associated with granules. The inclusions failed to react with antibodies against phosphorylated neurofilament or cystatin C. Most of the inclusions show no reaction with anti-ubiquitin antibody, however, a few inclusions show granular reaction product deposits with this antibody. The inclusions were not immunostained with antibodies against TGN46 and MG-160, markers of the trans-Golgi network and the medial cisternae of the Golgi apparatus respectively, suggesting that they were not derived from the Golgi apparatus which was fragmented. |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
ELSEVIER, Aizawa, H; Kimura, T; Hashimoto, K; Yahara, O; Okamoto, K; Kikuchi, K, JOURNAL OF THE NEUROLOGICAL SCIENCES, 176(2), 109-113, 2001.
\nauthor |
| 資源タイプ |
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内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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10930592 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1779 |
387.pdf (2.1 MB)
