| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2007-03-22 |
| タイトル |
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タイトル |
Convulsive seizures induced by N-methyl-D-aspartate microinjection into the mesencephalic reticular formation in rats |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
石本, 隆広
Omori, N
Muto, F
Chiba, S
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| 著者 ローマ字 |
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Ishimoto, Takahiro |
| 書誌情報 |
BRAIN RESEARCH
巻 881,
号 2,
p. 152-158,
発行日 2000-10-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0006-8993 |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/S0006-8993(00)02830-4 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.sciencedirect.com/science/journal/00068993 | http://www.sciencedirect.com/science/journal/00068993 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Effects of microinjections of a single 2 or 10 nmol dose of N-methyl-D-aspartate (NMDA) into the unilateral mesencephalic reticular formation (MRF) on behavior and electroencephalogram were examined in rats (n=18) during a 15 min period (Exp. 1), and subsequent effects of sound stimulation with key jingling applied at 15, 30, and 45 min after the injections were observed (Exp. 2). The microinjections of 2 nmol dose of NMDA (n=10) induced hyperactivity (9 of 10 rats) and running/circling (8 of 10 rats) in Exp. 1, and hyperactivity (3 of 10 rats) in Exp. 2. Moreover, the microinjections of 10 nmol dose of NMDA (n=8) induced not only hyperactivity (8 of 8 rats) and running/circling (7 of 8 rats) but also generalized tonic-clonic seizures (GTCS) (5 of 8 rats) in Exp. 1; these seizure patterns were also elicited by sound stimulation in Exp. 2. The seizure patterns were accompanied by electroencephalographic seizure discharges in the MRF and the motor cortex. In contrast, the control group rats (n=10) which received a single dose of saline microinjection into the unilateral MRF showed no behavioral or electroencephalographic changes in both Exp. 1 and 2. These findings suggest that the MRF has an important role in the development of GTCS, which follows hyperactivity and running/circling, and that potentiation of excitatory neurotransmission in the MRF participates in the development of audiogenic seizures as well as GTCS. |
| 注記 |
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内容記述タイプ |
Other |
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注記 |
ELSEVIER, Ishimoto, T; Omori, N; Mutoh, F; Chiba, S, BRAIN RESEARCH, 881(2), 152-158, 2000.
\nauthor |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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11036153 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1072 |
382.pdf (337.9 kB)
