{"created":"2023-06-19T11:22:08.724607+00:00","id":2434,"links":{},"metadata":{"_buckets":{"deposit":"41d52eb7-47b3-4ce9-b354-c14abf8b8571"},"_deposit":{"created_by":3,"id":"2434","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2434"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00002434","sets":["7","7:23"]},"author_link":["7585","7586","7587","7588","7589"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"19","bibliographicPageStart":"14","bibliographicVolumeNumber":"19","bibliographic_titles":[{"bibliographic_title":"旭川厚生病院医誌"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"成人型重症アトピー性皮膚炎に対して,シクロスポリンMECP(CyA)を食前投与し,投与量を変更しながら有用性とtherapeutic drug monitoring(TDM)を検討した。症例は2例でいずれもCyA投与により,皮疹の重症度スコアは劇的に改善し,かゆみvisual analogue scale(VAS)も改善した。いずれも,ステロイド外用剤の強さもストロンゲストクラスから,ストロングクラスへ減弱,または,タクロリムス外用剤へ変更できた。CyA投与量を平均3.1mg/kgから2.3mg/kgへと減量,維持量相当のトラフレベルは,平均87ng/ml,平均血中最高濃度は615ng/ml,0から4時間の血中濃度曲線下面積(area under the concentration-time curve0-4)は平均1943ng・hr/ml,となった。さらに一例は100mg/日の一日一回投与へ,一例は100mg/日の一日二回投与へとそれぞれ変更した。それぞれのトラフレベルは45ng/ml,79ng/ml,血中最高濃度は1100ng/ml,620ng/mlとなり,0から2時間の血中濃度曲線下面積(area under the concentration-time curve 0-2)は,それぞれ,1302ng・hr/ml,854ng・hr/mlとなった。一日一回食前投与のほうが血中最高濃度は高く,トラフレベルが低いため,効果的にみえるが,二回投与の0から2時間の血中濃度曲線下面積は24時間では2倍であり1302ng・hr/ml対1708ng・hr/mlとなるため,最小維持量である100mg/日投与では二回投与のほうが,持続的に効果がある可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載版","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0917-8066","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2010152675"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1243"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"704"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Nakamura, Satoshi"},{"subitem_text_language":"en","subitem_text_value":"Hashimoto, Yoshio"},{"subitem_text_language":"en","subitem_text_value":"Nishi, Kaoru"},{"subitem_text_language":"en","subitem_text_value":"Mizumoto, Toshihiro"},{"subitem_text_language":"en","subitem_text_value":"Takahashi, Hidetoshi"},{"subitem_text_language":"en"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中村, 哲史","creatorNameLang":"ja"},{"creatorName":"ナカムラ, サトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7585","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"橋本, 喜夫","creatorNameLang":"ja"},{"creatorName":"ハシモト, ヨシオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7586","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西, 薫"},{"creatorName":"ニシ, カオル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7587","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"水元, 俊裕","creatorNameLang":"ja"},{"creatorName":"ミズモト, トシヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7588","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋, 英俊"},{"creatorName":"タカハシ, ヒデトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7589","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"3464.pdf","filesize":[{"value":"5.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"3464.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/2434/files/3464.pdf"},"version_id":"1e0f862a-a932-41ed-ab4f-d5b46fc3cbe9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"重症成人型アトピー性皮膚炎","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"ＴＤＭ","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"シクロスポリンＭＥＣＰ","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"食前投与","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal 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