| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2010-11-01 |
| タイトル |
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タイトル |
High incidence of chromosomal abnormalities at 1p36 and 9p21 in early-stage central type squamous cell carcinoma and squamous dysplasia of bronchus detected by autofluorescence bronchoscopy |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
澁川, 紀代子
Miyokawa, N
Tokusashi, Y
Sasaki, T
Osanai, S
Ohsaki, Y
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| 著者 ローマ字 |
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Shibukawa, Kiyoko |
| 著者 ローマ字 |
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en |
| 書誌情報 |
Oncology Reports
巻 22,
号 1,
p. 81-87,
発行日 2009-07-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1021-335X |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.3892/or_00000409 |
| リンクURL |
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内容記述タイプ |
Other |
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内容記述 |
http://www.ncbi.nlm.nih.gov/pubmed?term=High%20incidence%20of%20chromosomal%20abnormalities%20at%201p36%20and%209p21%20in%20early-stage%20central%20type%20squamous%20cell%20carcinoma%20and%20squamous%20dysplasia%20of%20bronchus%20detected%20by%20autofluorescence%20bronchoscopy | http://www.ncbi.nlm.nih.gov/pubmed?term=High%20incidence%20of%20chromosomal%20abnormalities%20at%201p36%20and%209p21%20in%20early-stage%20central%20type%20squamous%20cell%20carcinoma%20and%20squamous%20dysplasia%20of%20bronchus%20detected%20by%20autofluorescence%20bronchoscopy |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Heavy smokers with central type squamous cell carcinoma (SCC) frequently have multiple cancerous lesions in the bronchus. Autofluorescence bronchoscopy (AFB) is useful in the detection of early bronchogenic cancer and dysplastic lesions. We investigated the loss of heterozygosity (LOH) and microsatellite instability (MSI) and expression of four proteins in 13 early stage SCC (early SCC) and 9 squamous dysplasia detected by AFB and 19 cases of surgically resected invasive SCC (invasive SCC). In early SCC and squamous dysplasia, LOH/MSI of chromosome 1p36 was found in 62 and 33%, respectively, and of 9p21 in 54 and 63%, respectively. TAp73 expression of early SCC and squamous dysplasia was lower than that of normal bronchial epithelium, and p16 expression was not detectable in these lesions. These results suggested that the genetic abnormalities had already developed in the early stage of carcinogenesis of SCC, including squamous dysplasia. The AFB system was able to reveal abnormal autofluorescence in these precancerous lesions, including squamous dysplasia. |
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言語 |
en |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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19513508 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1799 |
3416.pdf (285.4 kB)
