{"created":"2023-06-19T11:22:03.526666+00:00","id":2337,"links":{},"metadata":{"_buckets":{"deposit":"f22774bd-d4d6-4c1d-b579-1d7386eb96ea"},"_deposit":{"created_by":3,"id":"2337","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2337"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00002337","sets":["7","7:23"]},"author_link":["7168","7169","7170"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1986-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"208","bibliographicPageStart":"201","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"寄生虫学雑誌"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"旋毛虫(USA系)を300匹感染させたマウス(ICR系,雄,6週齢)をモデルとしてMebendazoleの投薬量,投薬回数,駆虫効果,副作用について検討した.Mebendazoleは原末を使用し,0.01%Cremophor(R) ELに所定量を懸濁して経口投薬した.成虫類はBaermann法で,幼虫数は筋肉消化法で算定した.腸管期または被嚢期に300, 180, 60, 30, 6 mg/kgの1回投薬と50, 30, 10, 5, 1 mg/kgの6日間連続投薬(総投薬量300, 180, 60, 30, 6 mg/kg)を行ない,成虫と幼虫に対する駆虫効果を比較した.成虫に対して1回投薬では300 mg/kgでも駆虫率は84.2%であったが,6日間連続投薬では総合投薬量60 mg/kgが90%以上の駆虫率を示す最低投薬量であった.幼虫に対して90%以上の駆虫率を示す最低投薬量は1回投薬では300 mg/kg, 6日間連続投薬では総投薬量60 mg/kgであった.6日間連続投薬が1回投薬よりも優れた駆虫効果を示した.駆虫率をプロビット変換して総投薬量のED50を計算すると,成虫に対するED50は1回投薬では32.4 mg/kg, 6日間連続投薬では4.3 mg/kgであり,成虫に対するED50は1回投薬では36.9 mg/kg, 6日間連続投薬では13.3 mg/kgであった.腸管期の治療群では副作用は全くみられなかったが,被嚢期の治療群では投薬量や投薬回数に関わらず,駆虫効果のみられた群に著明な体重減少がみられた","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載版","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-5171","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1987132218"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"875"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"732"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Nakao, Minoru"},{"subitem_text_language":"en","subitem_text_value":"Nakaya, Kazuhiro"},{"subitem_text_language":"en","subitem_text_value":"Kutsumi, Haruhiko"},{"subitem_text_language":"en"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中尾, 稔","creatorNameLang":"ja"},{"creatorName":"ナカオ, ミノル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7168","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中谷, 和宏","creatorNameLang":"ja"},{"creatorName":"ナカヤ, カズヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7169","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"久津見, 晴彦"},{"creatorName":"クツミ, ハルヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7170","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"3331.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"3331.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/2337/files/3331.pdf"},"version_id":"a817b0a8-3cf3-4a7c-97fa-023915e80749"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Trichinella spiralis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mouse","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mebendazole","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal 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