{"created":"2023-06-19T11:22:01.288715+00:00","id":2297,"links":{},"metadata":{"_buckets":{"deposit":"b071b3a1-6b31-4e9b-ae56-9e4bbddf6164"},"_deposit":{"created_by":3,"id":"2297","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2297"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00002297","sets":["7","7:23"]},"author_link":["7002","7003","7004","7005","7006","7007","7008"],"item_5_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"インターロイキン6-634C/G多型と喫煙との相互作用が、血清中C反応性タンパク質濃度に及ぼす作用","subitem_alternative_title_language":"ja"}]},"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-07-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"599","bibliographicPageStart":"593","bibliographicVolumeNumber":"30","bibliographic_titles":[{"bibliographic_title":"Hypertension Research"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"喫煙とインターロイキン6(IL6)は炎症の主要因子である。本試験では、日本の運送業の男性従業員347名を対象に、IL6-634C/G多型 (rs1800796)とその喫煙との相互作用が、血清中C反応性タンパク質(CRP)濃度に影響を及ぼすかどうかを検討した。IL6-634C/G多型の遺伝子型を決定した。年齢、体格指数(BMI)、収縮期圧などで調整後、非喫煙者より現喫煙者において平均CRPが有意に高かった。3つの遺伝子型を比較したところ、喫煙とCRP濃度によって現れるIL6-634C/Gとの間には有意な相互作用が認められた。喫煙状況を層別化したところ、CRPは、非喫煙者のIL6-634C/Gの遺伝子型グループ間で有意に異なっていたが、現喫煙者には有意差が認められなかった。-634C/CとC/G+G/Gとを比較しても、喫煙者とIL6-634C/G遺伝子型との間に有意な相互作用が認められた。以上より、-634G対立遺伝子がCRP上昇に及ぼす影響は、現喫煙者よりも非喫煙者の方が大きいことが示唆される。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"著者最終原稿版","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-9636","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2008033596"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1778"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"766"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Saijo, Yasuaki"},{"subitem_text_language":"en"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西條, 泰明","creatorNameLang":"ja"},{"creatorName":"サイジョウ, ヤスアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"7002","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshioka, Eiji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7003","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukui, Tomonori"}],"nameIdentifiers":[{"nameIdentifier":"7004","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawaharada, Mariko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7005","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sata, Fumihiro"}],"nameIdentifiers":[{"nameIdentifier":"7006","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Hirokazu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7007","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kishi, Reiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7008","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"3146.pdf","filesize":[{"value":"348.6 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polymorphism","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"interaction","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of the Interaction between Interleukin-6 -634C/G Polymorphism and Smoking on Serum C-Reactive Protein Concentrations","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of the Interaction between Interleukin-6 -634C/G Polymorphism and Smoking on Serum C-Reactive Protein Concentrations","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["7","23"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-08-05"},"publish_date":"2010-08-05","publish_status":"0","recid":"2297","relation_version_is_last":true,"title":["Effects of the Interaction between Interleukin-6 -634C/G Polymorphism and Smoking on Serum C-Reactive Protein Concentrations"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-25T08:11:29.855740+00:00"}