| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2010-06-30 |
| タイトル |
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|
タイトル |
Clinical and experimental studies of epilepsy associated with focal cortical dysplasia |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| 著者 |
橋詰, 清隆
Tsuda, H
Hodozuka, A
Tanaka, T
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| 著者 ローマ字 |
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|
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Hashizume, Kiyotaka |
| 著者 ローマ字 |
|
|
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en |
| 書誌情報 |
Psychiatry & Clinical Neurosciences
巻 58,
号 3,
p. S26-S29,
発行日 2004-06-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1323-1316 |
| DOI |
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|
関連タイプ |
isVersionOf |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1111/j.1440-1819.2004.01244_7.x |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
http://dx.doi.org/110.1111/j.1440-1819.2004.01244_7.x | http://dx.doi.org/110.1111/j.1440-1819.2004.01244_7.x |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
The results of clinical and experimental studies on epilepsy associated with focal cortical dysplasia (FCD) are presented. We have been interested in the findings of abnormal increases in the numbers of small vessels in specimens of FCD resected from epilepsy patients. In the clinical study of 13 patients with epilepsy, specimens of FCD or dysembryoplastic neuroepithelial tumor (DNT) were examined using immunohistochemistry. The number of vessels in both lesions were greater than those in cortical specimens of autopsy cases without epilepsy. Because the vessels showed negative staining of VEGF, it was thought that the phenomenon of increase in the number of vessels was simply a hypervascularity, not a neovascularity. The local hypervascularity was expected to show local hyperperfusion in CBF-SPECT study, but interictal SPECT demonstrated local hypoperfusion and ictal SPECT showed hyperperfusion. This may have been caused by a functional change in those vessels. In the experimental study, we tried to make a new animal model of FCD to study epileptogenicity of FCD. When kainic acid had been infused into the neocortex in the neonatal rats, FCD was induced in adult Wistar rats. Histopathological examination revealed cortical dyslamination and abnormal neurons. On EEG, local spike bursts were elicited from the lesions, however, clinical seizures were not detected. Although the data are preliminary and observation over a longer period is required to determine whether spontaneous seizures will occur in this model, it is expected that this new model will be useful for studying epilepsy associated with FCD. |
|
言語 |
en |
| 注記 |
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|
内容記述タイプ |
Other |
|
注記 |
The definitive version is available at www.blackwell-synergy.com |
|
言語 |
en |
| 資源タイプ |
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内容記述タイプ |
Other |
|
資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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15149312 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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|
1155 |
3085.pdf (399.0 kB)
