{"created":"2023-06-19T11:21:53.872846+00:00","id":2177,"links":{},"metadata":{"_buckets":{"deposit":"c7960d2d-bf02-43d0-b653-fb63d6fdacf5"},"_deposit":{"created_by":3,"id":"2177","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2177"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00002177","sets":["7","7:23"]},"author_link":["6575"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"15","bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"大和證券ヘルス財団の助成による研究業績集"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ミオシンATPaseに結合すると,そのATPase活性や筋収縮を阻害してしまうペプチドが天然に実際に存在することが明らかとなった.一方,ミオシンATPase側にも,基質ATPが結合する部位以外に,阻害剤の結合により筋収縮のエネルギー変換のプロセスが妨げられてしまうような重要部位の存在することも示唆された.ミオシンATPase阻害ペプチドの原料となる沖縄産海綿を大量に採集してそのアミノ酸一次構造を決定し,さらにミオシンATPase上でのペプチドの作用部位も決定されると,このペプチドを使った人為的な筋無力状態モデルを確立することが可能になり,これを進行性筋ジストロフィー症治療剤開発に応用できる","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載版","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1992142210"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1099"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"483"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Hiratsuka, Toshiaki"},{"subitem_text_language":"en"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平塚, 寿章","creatorNameLang":"ja"},{"creatorName":"ヒラツカ, トシアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"6575","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"3008.pdf","filesize":[{"value":"726.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"3008.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/2177/files/3008.pdf"},"version_id":"18bdd7cd-406e-40ff-98e3-ffd687488278"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ミオシンATPaseを阻害するペプチドの研究と進行性筋ジストロフィーの治療法開発への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ミオシンATPaseを阻害するペプチドの研究と進行性筋ジストロフィーの治療法開発への応用","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"3","path":["7","23"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-05-20"},"publish_date":"2010-05-20","publish_status":"0","recid":"2177","relation_version_is_last":true,"title":["ミオシンATPaseを阻害するペプチドの研究と進行性筋ジストロフィーの治療法開発への応用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-25T08:07:22.029864+00:00"}