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Inhibition of TNF-α-induced RANTES expression in human hepatocyte-derived cells by fibrates, the hypolipidemic drugs
https://asahikawa-med.repo.nii.ac.jp/records/207
https://asahikawa-med.repo.nii.ac.jp/records/207761aef73-f3cb-4e8a-972c-8dce8f434454
| 名前 / ファイル | ライセンス | アクション |
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248.pdf (414.8 kB)
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| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||||||||||
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| 公開日 | 2007-02-27 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Inhibition of TNF-α-induced RANTES expression in human hepatocyte-derived cells by fibrates, the hypolipidemic drugs | |||||||||||||
| 言語 | en | |||||||||||||
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| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
平野, 史倫
× 平野, 史倫
× Kobayashi, A
× Makino, I
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| 著者 ローマ字 | ||||||||||||||
| Hirano, Fuminori | ||||||||||||||
| 書誌情報 |
INTERNATIONAL IMMUNOPHARMACOLOGY 巻 3, 号 2, p. 225-232, 発行日 2003-02-01 |
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| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 1567-5769 | |||||||||||||
| DOI | ||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | 10.1016/S1567-5769(02)00275-8 | |||||||||||||
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| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | http://www.sciencedirect.com/science/journal/15675769 | http://www.sciencedirect.com/science/journal/15675769 | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Increased concentrations and activity of plasma cytokines produced by monocytes, macrophages, and hepatocytes in patients with alcoholic liver diseases, correlate with the clinical course of liver diseases and are of prognostic value. Especially, high levels of circulating tumor necrosis factor (TNF)-α have been found to correlate with increased mortality in alcoholic hepatitis. Moreover, hepatic RANTES was increased in patients with alcoholic hepatitis. Thus, TNF-α-induced RANTES expression may have a critical role in cell-mediated liver injury associated with alcoholic hepatitis. Fibrates are widely used in the treatment of hyperlipidemia and lower triglyceride levels in patients with hyperlipidemia. Recently, several groups reported that bezafibrate, one of fibrates, is effective in primary biliary cirrhosis treatment. Additionally, it is reported that bezafibrate is effective in the treatment not only of primary biliary cirrhosis but also of chronic hepatitis C and tamoxifen-induced non-alcoholic steatohepatitis. We, here, presented that bezafibrate and fenofibrate repressed TNF-α-induced protein production and mRNA expression of RANTES in human hepatocyte-derived cells. Luciferase assay showed that bezafibrate and fenofibrate inhibited RANTES gene expression in response to TNF-α. Moreover, bezafibrate repressed TNF-α-induced DNA-binding activity of NF-kB. Thus, fibrates reduced TNF-α-induced NF-kB activation and RANTES expression, possibly suggesting that fibrates might be inhibitory agents of migration of inflammatory cells by RANTES to the liver in patients with alcoholic liver diseases. In line of these results, it might be possible that fibrates are therapeutic agents in alcoholic liver diseases. | |||||||||||||
| 注記 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 注記 | ELSEVIER, Hirano, F; Kobayashi, A; Makino, I, INTERNATIONAL IMMUNOPHARMACOLOGY, 3(2), 225-232, 2003. \nauthor |
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| 資源タイプ | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 資源タイプ | text | |||||||||||||
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| 出版タイプ | AM | |||||||||||||
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| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | application/pdf | |||||||||||||
| ID(XooNIps) | ||||||||||||||
| 12586603 | ||||||||||||||
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| 1096 | ||||||||||||||
