{"created":"2023-06-19T11:21:48.203581+00:00","id":2061,"links":{},"metadata":{"_buckets":{"deposit":"2616bcdb-ffee-454f-a423-46bbbde8aae9"},"_deposit":{"created_by":3,"id":"2061","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"2061"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00002061","sets":["7","7:24"]},"author_link":["6172","6173","6174","6175","6176","6177","6178","6179","6180","6181"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"352","bibliographicPageStart":"348","bibliographicVolumeNumber":"382","bibliographic_titles":[{"bibliographic_title":"Biochemical and Biophysical Research Communications"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://www.ncbi.nlm.nih.gov/pubmed?term=A%20Jak2%20inhibitor%2C%20AG490%2C%20reverses%20lipin-1%20suppression%20by%20TNF-%CE%B1%20in%203T3-L1%20adipocytes | http://www.ncbi.nlm.nih.gov/pubmed?term=A%20Jak2%20inhibitor%2C%20AG490%2C%20reverses%20lipin-1%20suppression%20by%20TNF-%CE%B1%20in%203T3-L1%20adipocytes","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Lipin-1 is a multifunctional metabolic regulator, involving in triacylglycerol and bioactive glycerolipids synthesis as an enzyme, transcriptional regulation as a coactivator, and adipogenesis. In obesity, adipose lipin-1 expression is decreased. Although lipin-1 is implicated in the pathogenesis of obesity, the mechanism is still not clear. Since TNF-α is deeply involved in the pathogenesis of obesity, insulin resistance, and diabetes, here we investigated the role of TNF-α on lipin-1 expression in adipocytes. Quantitative PCR studies showed that TNF-α suppressed both lipin-1A and -1B isoform expression in time- and dose-dependent manners in mature 3T3-L1 adpocytes. A Jak2 inhibitor, AG490, reversed the suppressive effect of TNF-α on both lipin-1A and -1B. In contrast, NF-κB, MAPKs, ceramide, and β-catenin pathway tested were not involved in the mechanism. These results suggest that TNF-α could be involved in obesity-induced lipin-1 suppression in adipocytes and Jak2 may play an important role in the mechanism.","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"http://dx.doi.org/10.1016/j.bbrc.2009.03.021","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_relation_24":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.bbrc.2009.03.021","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0006-291X","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"19281795"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"3168"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1456"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Takahashi, Nobuhiko"},{"subitem_text_language":"en"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高橋, 伸彦","creatorNameLang":"ja"},{"creatorName":"タカハシ, ノブヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"6172","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tauchiya, Y","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6173","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshizaki, T"}],"nameIdentifiers":[{"nameIdentifier":"6174","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanno, S","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6175","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohhira, M"}],"nameIdentifiers":[{"nameIdentifier":"6176","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Motomura, W","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6177","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanno, S","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6178","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takakusaki, K","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6179","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kohgo, Y","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6180","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okumura, T","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"6181","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"2826.pdf","filesize":[{"value":"313.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2826.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/2061/files/2826.pdf"},"version_id":"e1f3ebe0-cf43-4d8f-828b-86e1319af067"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-α in 3T3-L1 adipocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-α in 3T3-L1 adipocytes","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2010-02-01"},"publish_date":"2010-02-01","publish_status":"0","recid":"2061","relation_version_is_last":true,"title":["A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-α in 3T3-L1 adipocytes"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-25T08:03:49.419362+00:00"}