| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2010-02-01 |
| タイトル |
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タイトル |
A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-α in 3T3-L1 adipocytes |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
高橋, 伸彦
Tauchiya, Y
Yoshizaki, T
Tanno, S
Ohhira, M
Motomura, W
Tanno, S
Takakusaki, K
Kohgo, Y
Okumura, T
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| 著者 ローマ字 |
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Takahashi, Nobuhiko |
| 著者 ローマ字 |
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|
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en |
| 書誌情報 |
Biochemical and Biophysical Research Communications
巻 382,
号 2,
p. 348-352,
発行日 2009-05-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0006-291X |
| DOI |
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関連タイプ |
isVersionOf |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.bbrc.2009.03.021 |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
http://www.ncbi.nlm.nih.gov/pubmed?term=A%20Jak2%20inhibitor%2C%20AG490%2C%20reverses%20lipin-1%20suppression%20by%20TNF-%CE%B1%20in%203T3-L1%20adipocytes | http://www.ncbi.nlm.nih.gov/pubmed?term=A%20Jak2%20inhibitor%2C%20AG490%2C%20reverses%20lipin-1%20suppression%20by%20TNF-%CE%B1%20in%203T3-L1%20adipocytes |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Lipin-1 is a multifunctional metabolic regulator, involving in triacylglycerol and bioactive glycerolipids synthesis as an enzyme, transcriptional regulation as a coactivator, and adipogenesis. In obesity, adipose lipin-1 expression is decreased. Although lipin-1 is implicated in the pathogenesis of obesity, the mechanism is still not clear. Since TNF-α is deeply involved in the pathogenesis of obesity, insulin resistance, and diabetes, here we investigated the role of TNF-α on lipin-1 expression in adipocytes. Quantitative PCR studies showed that TNF-α suppressed both lipin-1A and -1B isoform expression in time- and dose-dependent manners in mature 3T3-L1 adpocytes. A Jak2 inhibitor, AG490, reversed the suppressive effect of TNF-α on both lipin-1A and -1B. In contrast, NF-κB, MAPKs, ceramide, and β-catenin pathway tested were not involved in the mechanism. These results suggest that TNF-α could be involved in obesity-induced lipin-1 suppression in adipocytes and Jak2 may play an important role in the mechanism. |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
http://dx.doi.org/10.1016/j.bbrc.2009.03.021 |
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言語 |
en |
| 資源タイプ |
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内容記述タイプ |
Other |
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資源タイプ |
text |
| 著者版フラグ |
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出版タイプ |
AM |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
| ID(XooNIps) |
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19281795 |
| 閲覧数(XooNIps) |
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| ダウンロード数(XooNIps) |
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1456 |
2826.pdf (313.4 kB)
