WEKO3
アイテム
Severe immune checkpoint inhibitor-associated gastritis: A case series and literature review
https://asahikawa-med.repo.nii.ac.jp/records/2000529
https://asahikawa-med.repo.nii.ac.jp/records/20005291d63bef4-272e-47ed-8951-43aaa1e63ff3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
35845030.pdf (1.2 MB)
|
.png)
|
| Item type | 学術雑誌論文 / Journal Article_02(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2025-06-18 | |||||
| タイトル | ||||||
| タイトル | Severe immune checkpoint inhibitor-associated gastritis: A case series and literature review | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ | journal article | |||||
| bibliographic_information |
en : Endoscopy international open 巻 10, 号 7, p. E982-E989, 発行日 2022-07-15 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | EISSN | |||||
| 収録物識別子 | 2196-9736 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1055/a-1839-4303 | |||||
| リンクURL | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1839-4303 | |||||
| 言語 | en | |||||
| item_1716186501932 | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 35845030 | |||||
| item_5_description_33 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background and study aims Recent advances in cancer treatment have involved the clinical application of immune checkpoint inhibitors (ICIs) for various type of cancers. The adverse events associated with ICIs are generally referred to as immune-related adverse events (irAEs). Gastrointestinal irAEs are a major disorder, but gastritis is not frequently observed. The aims of this study were to elucidate the clinical, endoscopic, and histological characteristics of irAE gastritis. Patients and methods Information on patients treated with ICIs were collected from a single institute over 3 years. IrAE gastritis was identified based on the clinical course and endoscopic and histopathological findings. Of the 359 patients treated with ICIs, four cases of irAE gastritis were identified in clinical records from the endoscopy unit. The endoscopic and histopathological findings were analyzed, and further immunohistochemical studies with immune subtype markers and programmed cell death ligand-1 (PD-L1) antibody were conducted. Results Among four patients with irAE gastritis, the remarkable endoscopic characteristics were network-pattern erosion, erythematous and edematous mucosa with thick purulent discharge, and fragile mucosa. Corresponding histological features were fibrinopurulent exudate, severe inflammatory cell infiltration, and epithalaxia, respectively. The PD-L1 expression rate was ≥ 1 % in the gastric tissue of all patients with gastritis. These patients were treated with prednisolone (PSL) and their symptoms improved within a few days to 2 weeks. Conclusions IrAE gastritis were characterized by specific endoscopic findings. The appropriate endoscopic diagnosis may lead to effective treatment with PSL. | |||||
| 言語 | en | |||||
| 注記 | ||||||
| 内容記述タイプ | Other | |||||
| 注記 | This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||
| 言語 | en | |||||
| 出版タイプ | ||||||
| 出版タイプ | VoR | |||||
| item_5_textarea_42 | ||||||
| en | ||||||
| The Author(s). | ||||||
