| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2025-06-13 |
| タイトル |
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タイトル |
Testis-specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
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キーワード |
ATM |
| キーワード |
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主題Scheme |
Other |
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キーワード |
ATR |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
ZDHHC11 |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
colorectal cancer |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
hnRNP G-T |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Yuki, Murakami
Hiroaki, Konishi
Mikihiro, Fujiya
Keitaro, Takahashi
Katsuyoshi, Ando
Nobuhiro, Ueno
Shin, Kashima
Kentaro, Moriichi
Hiroki, Tanabe
Toshikatsu, Okumura
|
| bibliographic_information |
en : Cancer medicine
巻 11,
号 19,
p. 3643-3656,
発行日 2022-10-01
|
| ISSN |
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|
収録物識別子タイプ |
EISSN |
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収録物識別子 |
2045-7634 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1002/cam4.4738 |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
https://onlinelibrary.wiley.com/doi/10.1002/cam4.4738 |
|
言語 |
en |
| item_1716186501932 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
PMID |
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関連識別子 |
35384384 |
| item_5_description_33 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Various heterogeneous nuclear ribonucleoproteins (hnRNPs) have been reported to be associated with cancer cell growth. However, it remains unclear whether hnRNP G-T, which is specifically expressed in the testis, is expressed in tumor cells, and whether hnRNP G-T expressed in colorectal cancer (CRC) cells is associated with tumor progression. We herein report that hnRNP G-T promoted cancer cell growth and stabilized mRNA of ZDHHC11 in CRC. The cell growth was inhibited by transfection of siRNA of hnRNP G-T in cancer cells, but not in non-cancerous epithelial cells. The tumor promotive effect of hnRNP G-T was confirmed in an HCT116 transplanted mouse model. RT-PCR and western blotting indicated the augmentation of hnRNP G-T in CRC in comparison to non-cancerous cells. The downregulation of hnRNP G-T inhibited cancer cell growth and promoted apoptosis in CRC. A transcriptome analysis combined with immunoprecipitation revealed that hnRNP G-T stabilized 174 mRNAs, including ZDHHC11 mRNA. The cell growth was also suppressed by the transfection of siRNA of ZDHHC11 and the mRNA and the protein expression were decreased by the transfection of siRNA of hnRNP G-T. These results suggested that hnRNP G-T promotes the cell growth of CRC by regulating the mRNA of ZDHHC11. Therefore, hnRNP G-T will be highlighted as an effective therapeutic target with less adverse effects in CRC therapy |
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言語 |
en |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided
the original work is properly cited. |
|
言語 |
en |
| 出版タイプ |
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出版タイプ |
VoR |
| item_5_textarea_42 |
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|
en |
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© 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. |
35384384.pdf (8 MB)
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