| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2025-05-16 |
| タイトル |
|
|
タイトル |
Immunotherapy targeting tumor-associated antigen in a mouse model of head and neck cancer |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
adjuvant |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
c-Met |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
head and neck cancer |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
peptide vaccine |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
tumor‐associated antigen |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Michihisa, Kono
Risa, Wakisaka
Hiroki, Komatsuda
Ryusuke, Hayashi
Takumi, Kumai
Hidekiyo, Yamaki
Ryosuke Sato
Toshihiro, Nagato
Takayuki, Ohkuri
Akemi, Kosaka
Kenzo, Ohara
Kan, Kishibe
Hiroya, Kobayashi
Tatsuya, Hayashi
Miki, Takahara
|
| bibliographic_information |
en : Head and neck
巻 46,
号 8,
p. 2056-2067,
発行日 2024-02-23
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1043-3074 |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
1097-0347 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1002/hed.27703 |
| item_1716186501932 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
38390628 |
| item_5_description_33 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: The identification of epitope peptides from tumor-associated antigens (TAAs) is informative for developing tumor-specific immunotherapy. However, only a few epitopes have been detected in mouse TAAs of head and neck cancer (HNSCC).
Methods: Novel mouse c-Met-derived T-cell epitopes were predicted by computer-based algorithms. Mouse HNSCC cell line-bearing mice were treated with a c-Met peptide vaccine. The effects of CD8 and/or CD4 T-cell depletion, and vaccine combination with immune checkpoint inhibitors (ICIs) were evaluated. Tumor re-inoculation was performed to assess T-cell memory.
Results: We identified c-Met-derived short and long epitopes that elicited c-Met-reactive antitumor CD8 and/or CD4 T-cell responses. Vaccination using these peptides showed remarkable antitumor responses via T cells in which ICIs were not required. The c-Met peptide-vaccinated mice rejected the re-inoculated tumors.
Conclusions: We demonstrated that novel c-Met peptide vaccines can induce antitumor T-cell response, and could be a potent immunotherapy in a syngeneic mouse HNSCC model |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
AM |
| item_5_textarea_42 |
|
|
|
en |
|
|
© 2024 Wiley Periodicals LLC. |
38390628.pdf (1.6 MB)
