| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2025-05-14 |
| タイトル |
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タイトル |
Probiotic-derived heptelidic acid exerts antitumor effects on extraintestinal melanoma through glyceraldehyde-3-phosphate dehydrogenase activity control |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
Glyceraldehyde-3-phosphate dehydrogenase |
| キーワード |
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主題Scheme |
Other |
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キーワード |
Heptelidic acid |
| キーワード |
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主題Scheme |
Other |
|
キーワード |
Melanoma |
| 資源タイプ |
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資源タイプ |
journal article |
| アクセス権 |
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|
アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Shotaro, Isozaki
Hiroaki, Konishi
Hiroki, Tanaka
Chikage, Yamamura
Kentaro, Moriichi
Naoki, Ogawa
Mikihiro, Fujiya
|
| bibliographic_information |
en : BMC microbiology
巻 22,
号 1,
p. 110,
発行日 2022-04-22
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| ISSN |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
1471-2180 |
| DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1186/s12866-022-02530-0 |
| リンクURL |
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内容記述タイプ |
Other |
|
内容記述 |
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-022-02530-0 |
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言語 |
en |
| item_1716186501932 |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
PMID |
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関連識別子 |
35459092 |
| item_5_description_33 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background: Several microorganisms inhabit the mammalian gastrointestinal tract and are associated with the pathogenesis of various diseases, including cancer. Recent studies have indicated that several probiotics produce antitumor molecules and inhibit host tumor progression. We demonstrated that heptelidic acid (HA), a sesquiterpene lactone derived from the probiotic Aspergillus oryzae, exerts antitumor effects against pancreatic cancer in vitro and in vivo. In this study, the antitumor effects of HA against extraintestinal melanoma were assessed in vitro and in vivo.
Results: Sulforhodamine B (SRB) assay revealed that the growth of B16F10 cells was significantly inhibited by HA in a concentration-dependent manner. The enzymatic activity of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) decreased in proportion with the growth inhibition effect of HA. Moreover, oral HA administration significantly suppressed the growth of transplanted B16F10 tumors without any significant changes in biochemical test values. Moreover, GAPDH activity in the transplanted tumor tissues in the HA group significantly decreased compared with that in the PBS group.
Conclusion: This study suggests that orally administered HA was absorbed in the gastrointestinal tract, reached the cancer cells transplanted in the skin, and inhibited GAPDH activity, thereby inhibiting the growth of extraintestinal melanoma cells. Thus, this study proposes a novel system for extraintestinal tumor regulation via gut bacteria-derived bioactive mediators. |
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言語 |
en |
| 注記 |
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内容記述タイプ |
Other |
|
注記 |
© 2022. The Author(s). |
|
言語 |
en |
| 出版タイプ |
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出版タイプ |
VoR |
| item_5_textarea_42 |
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en |
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This article is licensed under a Creative Commons Attribution 4.0 International License |
35459092.pdf (1.6 MB)
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