| Item type |
学術雑誌論文 / Journal Article_02(1) |
| 公開日 |
2025-05-07 |
| タイトル |
|
|
タイトル |
Imeglimin prevents visceral hypersensitivity and colonic hyperpermeability in irritable bowel syndrome rat model |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
Colonic permeability |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
Imeglimin |
| キーワード |
|
|
主題Scheme |
Other |
|
キーワード |
Visceral sensation |
| 資源タイプ |
|
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
野津, 司
宮岸, 沙織
石王, 応知
高草木, 薫
奥村, 利勝
|
| bibliographic_information |
en : Journal of Pharmacological Sciences
巻 153,
号 1,
p. 26-30,
発行日 2023-09-01
|
| ISSN |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
1347-8613 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.1016/j.jphs.2023.07.002 |
| item_1716186501932 |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
37524451 |
| item_5_description_33 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Visceral hypersensitivity and leaky gut, which are mediated via corticotropin-releasing factor (CRF) and Toll-like receptor 4 are key pathophysiology of irritable bowel syndrome (IBS). Metformin was reported to improve these gastrointestinal (GI) changes. In this study, we attempted to determine the effects of imeglimin, which was synthesized from metformin on GI function in IBS rat models. Imeglimin blocked lipopolysaccharide- or CRF-induced visceral hypersensitivity and colonic hyperpermeability. These effects were prevented by compound C or naloxone. These results suggest that imeglimin may be effective for the treatment of IBS by improved visceral sensation and colonic barrier via AMPK and opioid receptor. |
|
言語 |
en |
| 出版タイプ |
|
|
出版タイプ |
AM |
37524451.pdf (2.5 MB)
.png)
