{"created":"2023-06-19T11:21:29.710873+00:00","id":1719,"links":{},"metadata":{"_buckets":{"deposit":"38410148-fef9-41ce-80ba-23e3dbe9f511"},"_deposit":{"created_by":3,"id":"1719","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1719"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00001719","sets":["7","7:23"]},"author_link":["5235"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"81","bibliographicPageStart":"73","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"臨床環境医学"}]}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"鉄代謝の特徴は、鉄を吸収する機構は存在するが、排泄する能動的機構が存在しないことである。鉄過剰症は遺伝的素因、頻回輸血、その他慢性肝疾患、アルコール摂取などの疾患で生じ、肝臓、心臓、中枢神経など生命維持に重要な臓器を障害する。鉄原子は、単独では細胞間、細胞膜、細胞内を移動できず、キャリアーないしトランスポーターを必要としており、血清中ではトランスフェリンが、小腸での鉄吸収には、divalent metal transporter 1(DMT1)が担っている。DMTは日本人の軍神宏美博士により初めてクローニングされた。このトランスポーターは他の微量金属も共有して使用しているため、金属中毒と極めて密接に関連している。さらに、細胞からのエクスポーターであるferroportin1や、生体の鉄代謝を統合的に制御するペプチド、ヘプシジンも同定され、生体の鉄代謝の全貌が明らかになりつつある。鉄過剰症に伴う臓器障害に対し、瀉血や鉄キレート剤などによる生体鉄を制御する治療法が有効である。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"出版社版","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-9407","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"2009138633"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"4814"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Kohgo, Yutaka"},{"subitem_text_language":"en"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高後, 裕","creatorNameLang":"ja"},{"creatorName":"コウゴ, ユタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"2258.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2258.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/1719/files/2258.pdf"},"version_id":"50410cce-b927-4986-a080-eab970cec3bf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"鉄","subitem_subject_scheme":"Other"},{"subitem_subject":"トランスフェリン","subitem_subject_scheme":"Other"},{"subitem_subject":"DMT1","subitem_subject_scheme":"Other"},{"subitem_subject":"フェロポーチン１","subitem_subject_scheme":"Other"},{"subitem_subject":"ヘプシジン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article"}]},"item_title":"鉄・酸化ストレスと内科疾患―軍神宏美博士を偲んで―","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"鉄・酸化ストレスと内科疾患―軍神宏美博士を偲んで―","subitem_title_language":"ja"}]},"item_type_id":"5","owner":"3","path":["7","23"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-07-07"},"publish_date":"2009-07-07","publish_status":"0","recid":"1719","relation_version_is_last":true,"title":["鉄・酸化ストレスと内科疾患―軍神宏美博士を偲んで―"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-25T07:56:19.694709+00:00"}