{"created":"2023-06-19T11:21:24.408851+00:00","id":1610,"links":{},"metadata":{"_buckets":{"deposit":"d7bfffdf-e64d-428b-a1ec-d480bdd8c211"},"_deposit":{"created_by":3,"id":"1610","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"1610"},"status":"published"},"_oai":{"id":"oai:asahikawa-med.repo.nii.ac.jp:00001610","sets":["7","7:24"]},"author_link":["5006","5007","5008","5009","5010","5011","5012"],"item_5_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"16","bibliographicPageEnd":"2039","bibliographicPageStart":"2035","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"Neuroreport"}]}]},"item_5_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"http://journals.lww.com/neuroreport/pages/default.aspx | http://journals.lww.com/neuroreport/pages/default.aspx","subitem_description_type":"Other"}]},"item_5_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"An in situ approach was used to identify the oxidized nucleoside, 8-hydroxyguanosine in brains of dementia with Lewy bodies. Neurons with marked immunoreaction of 8-hydroxyguanosine in the cytoplasm were widely distributed in the hippocampal region and temporal neocortex. Relative intensity measurements of neuronal 8-hydroxyguanosine immunoreactivity showed that there was a significant increase in nucleic acid oxidation in dementia with Lewy bodies compared with controls. Treatment with nuclease (DNase or RNase) before the immunostaining demonstrated that RNA was a major site of nucleic acid oxidation. Together with the previously reported RNA oxidation in vulnerable neurons in Alzheimer and Parkinson diseases, neuronal RNA oxidation in dementia with Lewy bodies might represent one of the fundamental abnormalities in age-associated neurodegenerative diseases.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_description_36":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"This is a non-final version of an article published in final form in Nunomura, Akihiko ; Chiba, Shigeru ; Kosaka, Kenji ; Takeda, Atsushi ; Castellani, Rudy J. ; Smith, Mark A. ; Perry, George, Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies, Neuroreport 13(16), NOV 2002, pp. 2035-2039\n\\nauthor","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"text","subitem_description_type":"Other"}]},"item_5_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0959-4965","subitem_source_identifier_type":"ISSN"}]},"item_5_text_44":{"attribute_name":"ID(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"12438921"}]},"item_5_text_54":{"attribute_name":"閲覧数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1908"}]},"item_5_text_55":{"attribute_name":"ダウンロード数(XooNIps)","attribute_value_mlt":[{"subitem_text_value":"1098"}]},"item_5_text_7":{"attribute_name":"著者 ローマ字","attribute_value_mlt":[{"subitem_text_value":"Nunomura, Akihiko"},{"subitem_text_language":"en"}]},"item_5_version_type_38":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"布村, 明彦","creatorNameLang":"ja"},{"creatorName":"ヌノムラ, アキヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"5006","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chiba, S","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"5007","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kosaka, K"}],"nameIdentifiers":[{"nameIdentifier":"5008","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeda, A","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"5009","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Castellani, RJ"}],"nameIdentifiers":[{"nameIdentifier":"5010","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Smith, MA","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"5011","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Perry, G","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"5012","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-06"}],"displaytype":"detail","filename":"2140.pdf","filesize":[{"value":"344.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2140.pdf","url":"https://asahikawa-med.repo.nii.ac.jp/record/1610/files/2140.pdf"},"version_id":"b2a0fd9c-9468-4577-89ec-e166f6c3e9d2"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies","subitem_title_language":"en"}]},"item_type_id":"5","owner":"3","path":["7","24"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2009-05-15"},"publish_date":"2009-05-15","publish_status":"0","recid":"1610","relation_version_is_last":true,"title":["Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-25T07:53:47.804399+00:00"}